Ethambutol analogues as potential antimycobacterial agents

被引：27

作者：

Häusler, H

Kawakami, RP

Mlaker, E

Severn, WB

Stütz, AE

机构：

[1] Graz Tech Univ, Inst Organ Chem, Glycogrp, A-8010 Graz, Austria

[2] AgRes, Wallaceville Anim Res Ctr, Upper Hutt, New Zealand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00258-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1679 / 1681

页数：3

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