An approach to combinatorial library generation of galactofuranose mimics as potential inhibitors of mycobacterial cell wall biosynthesis:: Synthesis of a peptidomimetic of uridine 5′-diphosphogalactofuranose (UDP-Galf)

被引：59

作者：

Lee, RE

Smith, MD

Pickering, L

Fleet, GWJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford Ctr Mol Sci, Oxford OX1 3QY, England

[2] NAID, Host Def Lab, DIR, NIH, Rockville, MD 20852 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 49期

关键词：

amide; combinatorial chemistry; tuberculosis; galactofuranose; transferase; inhibition;

D O I：

10.1016/S0040-4039(99)01844-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An approach to the synthesis of amide libraries based upon an alpha-iminogalactofuranose template as potential inhibitors of mycobacterial cell wall biosynthesis is described. The synthesis of peptide analogues of uridine 5'-phosphogalactofuranose (UDP-Galf) is also described. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：8689 / 8692

页数：4

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