Myrtenal inhibits acetylcholinesterase, a known Alzheimer target

被引：67

作者：

Kaufmann, Dorothea ^{[1
]}

Dogra, Anudeep Kaur ^{[2
]}

Wink, Michael ^{[1
]}

机构：

[1] Univ Heidelberg, Inst Pharm & Mol Biotechnol, Dept Biol, D-69120 Heidelberg, Germany

[2] Univ London, Sch Pharm, Ctr Pharmacognosy & Phytotherapy, London WC1N 1AX, England

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 2011年 / 63卷 / 10期

关键词：

acetylcholinesterase inhibitor; Alzheimer's disease; monoterpenes; myrtenal; ESSENTIAL OILS; DISEASE; PLANTS; COMPONENTS; TRIAL;

D O I：

10.1111/j.2042-7158.2011.01344.x

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

Objectives Inhibition of acetylcholinesterase (AChE) is a common treatment for early stages of the most general form of dementia, Alzheimer's disease. In this study selected components of essential oils, which carry a variety of important functional groups, were tested for their in-vitro anti-acetylcholinesterase activity. Methods In-vitro anti-acetylcholinesterase activity was measured by an adapted version of Ellman's colorimetric assay. Key findings 1,8-cineole, carvacrol, myrtenal and verbenone apparently inhibited AChE; the highest inhibitory activity was observed for myrtenal (IC50 = 0.17 mM). This is the first study showing the AChE inhibitory activity of myrtenal. Conclusions Our investigations provided evidence for the efficacy of monoterpenes as inhibitors of AChE.

引用

页码：1368 / 1371

页数：4

共 29 条

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Plants traditionally used in age related brain disorders -: A survey of ethnobotanical literature [J].