Comparative Study on the Antiviral Activity of Selected Monoterpenes Derived from Essential Oils

被引:268
作者
Astani, Akram [1 ,2 ]
Reichling, Juergen [3 ]
Schnitzler, Paul [1 ]
机构
[1] Univ Heidelberg, Dept Virol, Inst Hyg, D-69120 Heidelberg, Germany
[2] Yazd Shahid Sadoghi Univ Med Sci, Yazd, Iran
[3] Univ Heidelberg, Dept Biol, Inst Pharm & Mol Biotechnol, D-69120 Heidelberg, Germany
关键词
essential oils; monoterpenes; herpes simplex virus; antiviral activity; mode of action; selectivity index; HERPES-SIMPLEX-VIRUS; TEA TREE OIL; IN-VITRO; MELALEUCA-ALTERNIFOLIA; CELL-CULTURE; TOPICAL TREATMENT; PLANT-PRODUCTS; TYPE-1; LABIALIS; INFECTIONS;
D O I
10.1002/ptr.2955
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Essential oils are complex natural mixtures, their main constituents, e.g. terpenes and phenylpropanoids, being responsible for their biological properties. Essential oils from eucalyptus, tea tree and thyme and their major monoterpene compounds alpha-terpinene, gamma-terpinene, alpha-pinene, p-cymene, terpinen-4-ol, alpha-terpineol, thymol, citral and 1,8-cineole were examined for their antiviral activity against herpes simplex virus type 1 (HSV-1) in vitro. These essential oils were able to reduce viral infectivity by >96%, the monoterpenes inhibited HSV by about >80%. The mode of antiviral action has been determined, only moderate antiviral effects were revealed by essential oils and monoterpenes when these drugs were added to host cells prior to infection or after entry of HSV into cells. However, both essential oils and monoterpenes exhibited high anti-HSV-1 activity by direct inactivation of free virus particles. All tested drugs interacted in a dose-dependent manner with herpesvirus particles thereby inactivating viral infection. Among the analysed compounds, monoterpene hydrocarbons were slightly superior to monoterpene alcohols in their antiviral activity, a-pinene and a-terpineol revealed the highest selectivity index. However, mixtures of different nionoterpenes present in natural tea tree essential oil revealed a ten-fold higher selectivity index and a lower toxicity than its isolated single monoterpenes. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:673 / 679
页数:7
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