Fragile fugue: p53 in aging, cancer and IGF signaling

被引：29

作者：

Campisi, J ^{[1
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Buck Inst Age Res, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Lawrence Berkeley Lab, Div Life Sci, Berkeley, CA 94720 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 03期

关键词：

D O I：

10.1038/nm0304-231

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aging is driven in part by an evolutionarily conserved hormone signaling pathway. A new study shows that this pathway is controlled by the p53 tumor suppressor, which exquisitely balances the need for cell proliferation against that for tumor suppression.

引用

页码：231 / 232

页数：2

共 10 条

[1] The igf-1 receptor in cancer biology [J].

Baserga, R ;

Peruzzi, F ;

Reiss, K .

INTERNATIONAL JOURNAL OF CANCER, 2003, 107 (06) :873-877

[2] Extended longevity in mice lacking the insulin receptor in adipose tissue [J].

Blüher, M ;

Kahn, BB ;

Kahn, CR .

SCIENCE, 2003, 299 (5606) :572-574

[3] Cancer and ageing: Rival demons? [J].

Campisi, J .

NATURE REVIEWS CANCER, 2003, 3 (05) :339-349

[4] p53 protein variants: structural and functional similarities with p63 and p73 isoforms [J].

Courtois, S ;

de Fromentel, CC ;

Hainaut, P .

ONCOGENE, 2004, 23 (03) :631-638

[5] Genetic pathways that regulate ageing in model organisms [J].

Guarente, L ;

Kenyon, C .

NATURE, 2000, 408 (6809) :255-262

[6] IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice [J].

Holzenberger, M ;

Dupont, J ;

Ducos, B ;

Leneuve, P ;

Géloën, A ;

Even, PC ;

Cervera, P ;

Le Bouc, Y .

NATURE, 2003, 421 (6919) :182-187

[7] Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling [J].

Lin, AW ;

Barradas, M ;

Stone, JC ;

van Aelst, L ;

Serrano, M ;

Lowe, SW .

GENES & DEVELOPMENT, 1998, 12 (19) :3008-3019

[8] Evolutionary medicine: From dwarf model systems to healthy centenarians? [J].

Longo, VD ;

Finch, CE .

SCIENCE, 2003, 299 (5611) :1342-1346

[9] Modulation of mammalian life span by the short isoform of p53 [J].

Maier, B ;

Gluba, W ;

Bernier, B ;

Turner, T ;

Mohammad, K ;

Guise, T ;

Sutherland, A ;

Thorner, M ;

Scrable, H .

GENES & DEVELOPMENT, 2004, 18 (03) :306-319

[10] p53 mutant mice that display early ageing-associated phenotypes [J].

Tyner, SD ;

Venkatachalam, S ;

Choi, J ;

Jones, S ;

Ghebranious, N ;

Igelmann, H ;

Lu, XB ;

Soron, G ;

Cooper, B ;

Brayton, C ;

Park, SH ;

Thompson, T ;

Karsenty, G ;

Bradley, A ;

Donehower, LA .

NATURE, 2002, 415 (6867) :45-53

← 1 →