Oxidative stress parameters in erythrocytes of post-reperfused patients with myocardial infarction

被引：14

作者：

Bhakuni, P

Chandra, M

Misra, MK ^{[1
]}

机构：

[1] Univ Lucknow, Dept Biochem, Lucknow 226007, Uttar Pradesh, India

[2] King Georges Med Univ, Dept Med, Lucknow, Uttar Pradesh, India

来源：

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2005年 / 20卷 / 04期

关键词：

myocardial infarction; oxidative stress; ascorbic acid; antioxidants; lipid peroxidation; RBC's;

D O I：

10.1080/14756360500112409

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of reperfusion of patients with myocardial infarction on the levels of some anti-oxidant enzymes, total thiols, malondialdehyde formation in erythrocytes and plasma ascorbate levels have been investigated. Significantly decreased activities of catalase and superoxide dismutase and decreased levels of total thiols in RBC's and ascorbic acid in plasma suggest that reperfusion of the infarcted myocardium leads to oxidative stress conditions wherein anti-oxidant mechanisms become less effective in coping with the oxidative insult. This view is further supported by the observation that in the post reperfused patients there is a highly significant enhancement in the levels of malondialdehyde.

引用

页码：377 / 381

页数：5

共 38 条

[1] ASCORBATE INCREASES THE NUMBER OF LOW-DENSITY LIPOPROTEIN RECEPTORS IN CULTURED ARTERIAL SMOOTH-MUSCLE CELLS [J].