Fullerenes for Applications in Biology and Medicine

被引：177

作者：

Anilkumar, P. ^{[2
,3
]}

Lu, F. ^{[1
]}

Cao, L. ^{[2
,3
]}

Luo, P. G. ^{[2
,3
]}

Liu, J. -H. ^{[2
,3
]}

Sahu, S. ^{[2
,3
]}

Tackett, K. N., II ^{[2
,3
]}

Wang, Y. ^{[2
,3
]}

Sun, Y. -P. ^{[2
,3
]}

机构：

[1] Shantou Univ, Dept Chem, Shantou 515063, Guangdong, Peoples R China

[2] Clemson Univ, Dept Chem, Clemson, SC 29634 USA

[3] Clemson Univ, Lab Emerging Mat & Technol, Clemson, SC 29634 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2011年 / 18卷 / 14期

基金：

美国国家科学基金会;

关键词：

Fullerenes; radical scavengers; drug carriers; photodynamic therapy; endofullerenes; MRI contrast agents; OXYGEN SPECIES GENERATION; ANTI-HIV PROPERTIES; IN-VIVO; ENDOHEDRAL METALLOFULLERENE; PHOTODYNAMIC ACTIVITY; FUNCTIONALIZED FULLERENES; STRUCTURAL-PROPERTIES; C-60; FULLERENES; CONTRAST AGENT; MALONIC-ACID;

D O I：

10.2174/092986711795656225

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Fullerenes as a unique class of carbon allotropes have been studied extensively for their distinctive material properties and potential technological applications, including those in biology and medicine. Since a major focus in the latter has been on drug development and formulation, in this paper we highlight some representative studies related to such a focus, including the use of fullerenes for drug-like functions and for their improving the formulation of established drugs. Also discussed are some other potential medically relevant applications of fullerenes, such as their serving as potent agents in photodynamic therapy and magnetic imaging.

引用

页码：2045 / 2059

页数：15

共 103 条

[1]

Photodynamic activity of a new sensitizer derived from porphyrin-C60 dyad and its biological consequences in a human carcinoma cell line [J].