New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 -: I.: Taxonomy, fermentation, isolation and biological properties

被引：53

作者：

Fukuda, T

Arai, M

Yamaguchi, Y

Masuma, R

Tomoda, H

Omura, S

机构：

[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan

[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan

[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 02期

关键词：

D O I：

10.7164/antibiotics.57.110

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Three new beauvericins, designated beauvericins D, E and F, were isolated along with known beauvericin and beauvericin A, from the culture of Beauveria sp. FKI-1366 by solvent extraction, ODS column chromatography and HPLC. These compounds potentiate miconazole activity against not only wild Candida albicans but also fluconazole resistant C. albicans. Beauvericins D and E decreased the IC50 value of miconazole against fluconazole resistant C. albicans from 1.3 mum to 0.25 and 0.31 mum, respectively.

引用

页码：110 / 116

页数：7

共 19 条

[1] Funicone-related compounds, potentiators of antifungal miconazole activity, produced by Talaromyces flavus FKI-0076 [J].