New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 -: II.: Structure elucidation.

被引:52
作者
Fukuda, T
Arai, M
Tomoda, H
Omura, S
机构
[1] Kitasato Univ, Kitasato Inst Life Sci, Minato Ku, Tokyo 1088641, Japan
[2] Kitasato Univ, Grad Sch Infect Control Sci, Minato Ku, Tokyo 1088641, Japan
[3] Kitasato Inst, Minato Ku, Tokyo 1088642, Japan
关键词
D O I
10.7164/antibiotics.57.117
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The structures of beauvericins D, E and F, novel potentiators of miconazole activity against Candida albicans produced by Beauveria sp. FKI 1366, were elucidated by various spectroscopic analyses including UV NMR, and MS and degradation experiments. They have the common skeleton of the 18-membered cyclodepsipeptides.
引用
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页码:117 / 124
页数:8
相关论文
共 6 条
[1]   ISOLATION OF CYCLODEPSIPEPTIDES FROM PLANT PATHOGENIC FUNGI [J].
DEOL, BS ;
RIDLEY, DD ;
SINGH, P .
AUSTRALIAN JOURNAL OF CHEMISTRY, 1978, 31 (06) :1397-1399
[2]   New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp FKI-1366 -: I.: Taxonomy, fermentation, isolation and biological properties [J].
Fukuda, T ;
Arai, M ;
Yamaguchi, Y ;
Masuma, R ;
Tomoda, H ;
Omura, S .
JOURNAL OF ANTIBIOTICS, 2004, 57 (02) :110-116
[3]  
Logrieco A, 1998, APPL ENVIRON MICROB, V64, P3084
[4]   Precursor-directed biosynthesis of beauvericin analogs by the insect pathogenic fungus Paecilomyces tenuipes BCC 1614 [J].
Nilanonta, C ;
Isaka, M ;
Kittakoop, P ;
Trakulnaleamsai, S ;
Tanticharoen, M ;
Thebtaranonth, Y .
TETRAHEDRON, 2002, 58 (17) :3355-3360
[5]  
OVCHINNIKOV YA, 1971, TETRAHEDRON LETT, P159
[6]  
WILLIAMS LP, 1994, J CHEM SOC PERK T, P1969