Strategies to discover regulatory circuits of the mammalian immune system

被引：45

作者：

Amit, Ido ^{[1
,2
]}

Regev, Aviv ^{[1
,3
]}

Hacohen, Nir ^{[1
,4
,5
]}

机构：

[1] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[2] Weizmann Inst Sci, Dept Immunol, IL-76100 Rehovot, Israel

[3] MIT, Dept Biol, Howard Hughes Med Inst, Cambridge, MA 02142 USA

[4] Massachusetts Gen Hosp, Ctr Immunol & Inflammatory Dis, Charlestown, MA 02129 USA

[5] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; NONCODING RNAS; TRANSCRIPTIONAL NETWORK; DNA-DAMAGE; T-CELLS; BIOLOGY; CHROMATIN; DYNAMICS; DIFFERENTIATION; SIGNATURE;

D O I：

10.1038/nri3109

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent advances in technologies for genome- and proteome-scale measurements and perturbations promise to accelerate discovery in every aspect of biology and medicine. Although such rapid technological progress provides a tremendous opportunity, it also demands that we learn how to use these tools effectively. One application with great potential to enhance our understanding of biological systems is the unbiased reconstruction of genetic and molecular networks. Cells of the immune system provide a particularly useful model for developing and applying such approaches. Here, we review approaches for the reconstruction of signalling and transcriptional networks, with a focus on applications in the mammalian innate immune system.

引用

页码：873 / 880

页数：8

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