Fibronectin-Carbon-Nanotube Hybrid Nanostructures for Controlled Cell Growth

被引:64
作者
Namgung, Seon
Kim, Taekyeong
Baik, Ku Youn
Lee, Minbaek
Nam, Jwa-Min [1 ]
Hong, Seunghun [2 ]
机构
[1] Seoul Natl Univ, Dept Chem, Seoul 151747, South Korea
[2] Seoul Natl Univ, Dept Phys & Astron, Interdisciplinary Program Nanosci & Technol, Dept Biophys & Chem Biol, Seoul 151747, South Korea
基金
新加坡国家研究基金会;
关键词
DEFINED SURFACE CHEMISTRIES; MESENCHYMAL STEM-CELLS; ADHESION; PERFORMANCE; ADSORPTION; MATRIX; AFM;
D O I
10.1002/smll.201001513
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Fibronectin-carbon-nanotube (CNT) hybrid nanostructures are proposed as a platform to control the adhesion and growth of cells. The structure and role of extracellular matrix proteins, such as fibronectin, in the CNT-cell interactions are revealed by atomic force microscopy. The focal adhesion sites on fibronectin-carbon-nanotube hybrid nanostructures induce selective cell growth, including selective filopodial growth of human mesenchymal stem cells. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码:56 / 61
页数:6
相关论文
共 21 条
[11]   Linker-free directed assembly of high-performance integrated devices based on nanotubes and nanowires [J].
Lee, M. ;
Im, J. ;
Lee, B. Y. ;
Myung, S. ;
Kang, J. ;
Huang, L. ;
Kwon, Y. -K. ;
Hong, S. .
NATURE NANOTECHNOLOGY, 2006, 1 (01) :66-71
[12]   Stretching DNA [J].
Marko, JF ;
Siggia, ED .
MACROMOLECULES, 1995, 28 (26) :8759-8770
[13]   Force microscopy studies of fibronectin adsorption and subsequent cellular adhesion to substrates with well-defined surface chemistries [J].
Meadows, PY ;
Walker, GC .
LANGMUIR, 2005, 21 (09) :4096-4107
[14]   Adsorption-induced conformational changes in fibronectin due to interactions with well-defined surface chemistries [J].
Michael, KE ;
Vernekar, VN ;
Keselowsky, BG ;
Meredith, JC ;
Latour, RA ;
García, AJ .
LANGMUIR, 2003, 19 (19) :8033-8040
[15]   Conformational analysis of native fibronectin by means of force spectroscopy [J].
Oberdörfer, Y ;
Fuchs, H ;
Janshoff, A .
LANGMUIR, 2000, 16 (26) :9955-9958
[16]   The mechanical hierarchies of fibronectin observed with single-molecule AFM [J].
Oberhauser, AF ;
Badilla-Fernandez, C ;
Carrion-Vazquez, M ;
Fernandez, JM .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 319 (02) :433-447
[17]   Carbon nanotube monolayer patterns for directed growth of mesenchymal stem cells [J].
Park, Sung Young ;
Park, Sun Young ;
Namgung, Seon ;
Kim, Byeongju ;
Im, Jiwoon ;
Kim, Youn ;
Sun, Kyung ;
Lee, Kyu Back ;
Nam, Jwa-Min ;
Park, Yongdoo ;
Hong, Seunghun .
ADVANCED MATERIALS, 2007, 19 (18) :2530-+
[18]   Reversible unfolding of individual titin immunoglobulin domains by AFM [J].
Rief, M ;
Gautel, M ;
Oesterhelt, F ;
Fernandez, JM ;
Gaub, HE .
SCIENCE, 1997, 276 (5315) :1109-1112
[19]   Adapting collagen/CNT matrix in directing hESC differentiation [J].
Sridharan, Indumathi ;
Kim, Taeyoung ;
Wang, Rong .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 381 (04) :508-512
[20]   Cellular behavior of human mesenchymal stem cells cultured on single-walled carbon nanotube film [J].
Tay, Chor Yong ;
Gu, Haigang ;
Leong, Wen Shing ;
Yu, Haiyang ;
Li, Hua Qiong ;
Heng, Boon Chen ;
Tantang, Hosea ;
Loo, Say Chye Joachim ;
Li, Lain Jong ;
Tan, Lay Poh .
CARBON, 2010, 48 (04) :1095-1104