Palladium-catalyzed cyanation of aryl halides: Recent developments and perspectives

被引：225

作者：

Sundermeier, M ^{[1
]}

Zapf, A ^{[1
]}

Beller, M ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Organ Katlayse EV, D-18055 Rostock, Germany

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2003年 / 19期

关键词：

palladium; cyanation; benzonitriles; homogeneous catalysis;

D O I：

10.1002/ejic.200300162

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The palladium-catalyzed cyanation of aryl halides is an elegant method for the preparation of benzonitriles. Since its discovery in 1973, this reaction has been the topic of several investigations. Nevertheless, the general methodology is still somewhat underdeveloped compared to other palladium-catalyzed coupling reactions. Here, we summarize important developments from 1997 until 2003 in this area. Recent contributions from our group include the development of palladium/phosphane/amine catalyst systems for the cyanation of aryl chlorides, the successful cyanation of aryl halides with acetone cyanohydrin and trimethylsilyl cyanide as cyanation reagents, and a general improvement of catalyst efficiency by using a continuous dosage of cyanide sources. (C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.

引用

页码：3513 / 3526

页数：14

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