Time to rethink clinically important outcomes in platelet transfusion trials

被引:32
作者
Heddle, Nancy M. [1 ]
Arnold, Donald M.
Webert, Kathryn E.
机构
[1] McMaster Univ, HSC 3H50, Dept Med, Hamilton, ON L8N 3Z5, Canada
关键词
SURROGATE END-POINTS; COMPOSITE OUTCOMES; RANDOMIZED-TRIALS; PREVENTION;
D O I
10.1111/j.1537-2995.2010.02982.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:430 / 434
页数:5
相关论文
共 23 条
[1]   The use and abuse of surrogate endpoints in clinical research in transfusion medicine [J].
Arnold, Donald M. ;
Lim, Wendy .
TRANSFUSION, 2008, 48 (08) :1547-1549
[2]   SURROGATE END-POINTS - A BASIS FOR A RATIONAL APPROACH [J].
BOISSEL, JP ;
COLLET, JP ;
MOLEUR, P ;
HAUGH, M .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1992, 43 (03) :235-244
[3]   A COMPARISON OF FILTERED LEUKOCYTE-REDUCED AND CYTOMEGALOVIRUS (CMV) SERONEGATIVE BLOOD PRODUCTS FOR THE PREVENTION OF TRANSFUSION-ASSOCIATED CMV INFECTION AFTER MARROW TRANSPLANT [J].
BOWDEN, RA ;
SLICHTER, SJ ;
SAYERS, M ;
WEISDORF, D ;
CAYS, M ;
SCHOCH, G ;
BANAJI, M ;
HAAKE, R ;
WELK, K ;
FISHER, L ;
MCCULLOUGH, J ;
MILLER, W .
BLOOD, 1995, 86 (09) :3598-3603
[4]   Users' guides to the medical literature XIX. Applying clinical trial results A. How to use an article measuring the effect of an intervention on surrogate end points [J].
Bucher, HC ;
Guyatt, GH ;
Cook, DJ ;
Holbrook, A ;
McAlister, FA .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (08) :771-778
[5]   A randomized controlled clinical trial evaluating the performance and safety of platelets treated with MIRASOL pathogen reduction technology [J].
Cazenave, J. -P ;
Follea, G. ;
Bardiaux, L. ;
Boiron, J. -M. ;
Lafeuillade, B. ;
Debost, M. ;
Lioure, B. ;
Harousseau, J. -L. ;
Tabrizi, R. ;
Cahn, J. -Y ;
Michallet, M. ;
Ambruso, D. ;
Schots, R. ;
Tissot, J. -D. ;
Sensebe, L. ;
Kondo, T. ;
McCullough, J. ;
Rebulla, P. ;
Escolar, G. ;
Mintz, P. ;
Heddle, N. M. ;
Goodrich, R. P. ;
Bruhwyler, J. ;
Le, C. ;
Cook, R. J. ;
Stouch, B. .
TRANSFUSION, 2010, 50 (11) :2362-2375
[6]   Methods for the analysis of bleeding outcomes in randomized trials of PLT transfusion triggers [J].
Cook, RJ ;
Heddle, NM ;
Rebulla, P ;
Sigouin, CS ;
Webert, KE .
TRANSFUSION, 2004, 44 (08) :1135-1142
[7]   Definition, reporting, and interpretation of composite outcomes in clinical trials: systematic review [J].
Cordoba, Gloria ;
Schwartz, Lisa ;
Woloshin, Steven ;
Bae, Harold ;
Gotzsche, Peter C. .
BMJ-BRITISH MEDICAL JOURNAL, 2010, 341 :381
[8]   Composite outcomes in randomized trials - Greater precision but with greater uncertainty? [J].
Freemantle, N ;
Calvert, M ;
Wood, J ;
Eastaugh, J ;
Griffin, C .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (19) :2554-2559
[9]  
Gulliksson H, 2003, BLOOD, V101, P2426
[10]   A randomized controlled trial comparing standard- and low-dose strategies for transfusion of platelets (SToP) to patients with thrombocytopenia [J].
Heddle, Nancy M. ;
Cook, Richard J. ;
Tinmouth, Alan ;
Kouroukis, C. Tom ;
Hervig, Tor ;
Klapper, Ellen ;
Brandwein, Joseph M. ;
Szczepiorkowski, Zbigniew M. ;
AuBuchon, James P. ;
Barty, Rebecca L. ;
Lee, Ker-Ai .
BLOOD, 2009, 113 (07) :1564-1573