Synthesis of oligomers of tetrahydrofuran amino acids: furanose carbopeptoids

被引：65

作者：

Smith, MD

Long, DD

Marquess, DG

Claridge, TDW

Fleet, GWJ

机构：

[1] Univ Oxford, Dyson Perrins Lab, Oxford OX1 3QY, England

[2] Glaxo Wellcome Ltd, Stevenage SG1 2NY, Herts, England

[3] Adv Med Inc, S San Francisco, CA 94080 USA

来源：

CHEMICAL COMMUNICATIONS | 1998年 / 18期

关键词：

D O I：

10.1039/a805364b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An acid catalysed ring rearrangement of a triflate derivative of D-mannono-gamma-lactone 6 is the key step in the synthesis of the C-glycosyl sugar amino acid derivatives 3 and 4, examples of carbohydrate amino acid building blocks with specific conformational preferences suitable for incorporation into combinatorial amide libraries; homo-oligomerisation via solution phase coupling procedures affords furanose carbopeptoids 1 which adopt novel solution state secondary structures.

引用

收藏

页码：2039 / 2040

页数：2

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