Screening for genes involved in tissue invasion based on placenta formation and cancer cell lines with low and high metastatic potential

被引：9

作者：

Kataoka, K

Nakajima, A

Takata, Y

Saito, S

Huh, NH ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Fac Med, Dept Biochem, Toyama 9300194, Japan

[2] Toyama Med & Pharmaceut Univ, Fac Med, Dept Obstet & Gynecol, Toyama 9300194, Japan

来源：

CANCER LETTERS | 2001年 / 163卷 / 02期

关键词：

metastasis; cancer cell lines; placenta; differential display; gene;

D O I：

10.1016/S0304-3835(00)00685-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the formation of placenta, trophoblast cells vigorously invade maternal uterine tissues, sharing many features with the invasion of cancers. We applied RNA differential display to placenta tissues from 8.5 to 17.5 days post-coitus (dpc) ICR mice, and isolated 188 cDNA fragments expressed differentially. Among the 25 known cDNA fragments thus far analyzed, six cDNAs have been reported to be relevant to tumor invasion and/or metastasis. Furthermore, 11 of 20 unknown cDNAs isolated showed differential expression between the pairs of cancer cell lines with low and high metastatic potential, indicating potential usefulness of the present two-step approach. (C) 2001 Elsevier Science ireland Ltd. All rights reserved.

引用

页码：213 / 219

页数：7

共 34 条

[1]

APLIN JD, 1991, J CELL SCI, V99, P681

[2] Molecular classification of cutaneous malignant melanoma by gene expression profiling [J].