Antiproliferative, antioxidant, and antimutagenic activities of flavonoid-enriched extracts from (Tunisian) Rhamnus alaternus L.:: Combination with the phytochemical composition

被引：26

作者：

Ben Ammar, Rebai ^{[2
]}

Kilani, Soumaya ^{[2
]}

Bouhlel, Ines ^{[2
]}

Ezzi, Lobna

Skandrani, Ines ^{[2
]}

Boubaker, Jihed ^{[2
]}

Ben Sghaier, Mohamed ^{[2
]}

Naffeti, Aicha ^{[2
]}

Mahmoud, Amor ^{[2
]}

Chekir-Ghedira, Leila ^{[1
,2
]}

Ghedira, Kamel ^{[2
]}

机构：

[1] Fac Med Dent, Cellular & Mol Biol Lab, Monastir 5000, Tunisia

[2] Fac Pharm, Unite Pharmacog Biol Mol UR 99 0703, Monastir, Tunisia

来源：

DRUG AND CHEMICAL TOXICOLOGY | 2008年 / 31卷 / 01期

关键词：

Rhamnus alatemus (Rhamnacae); antioxidant effect; antimutagenic activity; antiproliferative effect; photochemical composition; MII; Ames test; DPPH; xanthine oxidase; superoxide anions;

D O I：

10.1080/01480540701688725

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A pronounced antiproliferative effect on human leukemia K562 cells was shown with flavonoid-enriched extracts from Rhamnus alaternus roots and leaves, with, respectively, IC50 values of 165 and 210.73 mu g/mL. High DPPH radical-scavenging activity (7.21 and 18.84 mu g/mL, respectively) and antioxidative effects using the xanthine oxidase assay (IC50 values of 83.33 and 103.96 mu g/mL, respectively) were detected in the presence of the two tested extracts. Although no mutagenic effect was observed when using the Salmonella typhimurium assay system with TA1535 and TA100 strains, the two tested extracts exhibited a high-level protection toward the direct mutagen, sodium azide-induced response.

引用

页码：61 / 80

页数：20

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