Effects of allogeneic bone marrow-derived mesenchymal stem cells on T and B lymphocytes from BXSB mice

被引：110

作者：

Deng, WN

Han, Q

Liao, LM

You, SG

Deng, HY ^{[1
]}

Zhao, RCH

机构：

[1] Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

[2] Chinese Acad Med Sci, Ctr Tissue Engn, Beijing 100037, Peoples R China

[3] Peking Union Med Coll, Beijing, Peoples R China

[4] Tianjin Med Univ, Dept Immunol, Tianjin, Peoples R China

来源：

DNA AND CELL BIOLOGY | 2005年 / 24卷 / 07期

关键词：

D O I：

10.1089/dna.2005.24.458

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bone marrow-derived mesenchymal stem cells (bMSCs) can differentiate into a number of different cell/tissue types, and also possess immunoregulatory functions. The present study was undertaken to elucidate the exact immunoregulatory effects of allogeneic bMSCs on T- and B-lymphocyte proliferation, activation, and function maturation of BXSB mice, which has been considered as a experimental model for human systemic lupus erythematosus (SLE). We determined that bMSCs from BALB/c mice had inhibitory effects on BXSB mice T- lymphocyte proliferation, but no inhibitory effect on their activation. In addition, they had a significant inhibitory and stimulatory effect on IL-4- and IFN-gamma-producing T cells, respectively. Also, bMSCs had inhibitory effects on the proliferation, activation, and IgG secretion of B lymphocytes. In addition, BALB/c bMSCs had an enhancing effect on CD40 expression and inhibitory effects on CD40 ligand (CD40L) ectopic hyperexpression on B cells from BXSB mice.

引用

页码：458 / 463

页数：6

共 26 条

[1] Quantitative and qualitative analysis of the balance between type 1 and type 2 cytokine-producing CD8- and CD8+ T cells in systemic lupus erythematosus [J].