Possible roles of DLK1 in the Notch pathway during development and disease

被引：152

作者：

Falix, Farah A. ^{[1
,2
]}

Aronson, Daniel C. ^{[2
]}

Lamers, Wouter H. ^{[1
]}

Gaemers, Ingrid C. ^{[1
]}

机构：

[1] Acad Med Ctr, Tytgat Inst Liver & Intestinal Res, NL-1105 BK Amsterdam, Netherlands

[2] Acad Med Ctr, Emma Childrens Hosp AMC, Pediat Surg Ctr Amsterdam, NL-1105 BK Amsterdam, Netherlands

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2012年 / 1822卷 / 06期

关键词：

DLK1; Notch pathway; Development; Adipose tissue; Liver; Pediatric tumor; INHIBITS ADIPOCYTE DIFFERENTIATION; AXIAL SKELETAL DEFECTS; EGF-LIKE REPEATS; FACTOR-I PREF-1; FETAL ANTIGEN 1; STEM-LIKE CELLS; EMBRYONIC LETHALITY; SIGNALING PATHWAY; PROGENITOR CELLS; PROTEIN DLK;

D O I：

10.1016/j.bbadis.2012.02.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The Delta-Notch pathway is an evolutionarily conserved signaling pathway which controls a broad range of developmental processes including cell fate determination, terminal differentiation and proliferation. In mammals, four Notch receptors (NOTCH1-4) and five activating canonical ligands (JAGGED1, JAGGED2, DLL1, DLL3 and DLL4) have been described. The precise function of noncanonical Notch ligands remains unclear. Delta-like 1 homolog (DLK1), the best studied noncanonical Notch ligand, has been shown to act as an inhibitor of Notch signaling in vitro, but its function in vivo is poorly understood. In this review we summarize Notch signaling during development and highlight recent studies in DLK1expression that reveal new insights into its function. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：988 / 995

页数：8

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