KIF5B-RET fusions in lung adenocarcinoma

被引：648

作者：

Kohno, Takashi ^{[1
]}

Ichikawa, Hitoshi ^{[2
]}

Totoki, Yasushi ^{[3
]}

Yasuda, Kazuki ^{[4
]}

Hiramoto, Masaki ^{[4
]}

Nammo, Takao ^{[4
]}

Sakamoto, Hiromi ^{[2
]}

Tsuta, Koji ^{[5
]}

Furuta, Koh ^{[5
]}

Shimada, Yoko ^{[1
]}

Iwakawa, Reika ^{[6
]}

Ogiwara, Hideaki ^{[1
]}

Oike, Takahiro ^{[6
]}

Enari, Masato ^{[7
]}

Schetter, Aaron J. ^{[8
]}

Okayama, Hirokazu ^{[6
,8
]}

Haugen, Aage ^{[9
]}

Skaug, Vidar ^{[9
]}

Chiku, Suenori ^{[10
]}

Yamanaka, Itaru ^{[11
]}

Arai, Yasuhito

Watanabe, Shun-ichi ^{[12
]}

Sekine, Ikuo ^{[13
]}

Ogawa, Seishi ^{[14
]}

Harris, Curtis C. ^{[8
]}

Tsuda, Hitoshi ^{[5
]}

Yoshida, Teruhiko ^{[2
]}

Yokota, Jun ^{[6
]}

Shibata, Tatsuhiro ^{[3
]}

机构：

[1] Natl Canc Ctr, Res Inst, Div Genome Biol, Chuo Ku, Tokyo 104, Japan

[2] Natl Canc Ctr, Res Inst, Div Genet, Chuo Ku, Tokyo 104, Japan

[3] Natl Canc Ctr, Res Inst, Div Canc Genom, Chuo Ku, Tokyo 104, Japan

[4] Natl Ctr Global Hlth & Med, Dept Metab Disorder, Diabet Res Ctr, Res Inst,Shinjuku Ku, Tokyo, Japan

[5] Natl Canc Ctr, Div Pathol & Clin Labs, Chuo Ku, Tokyo, Japan

[6] Natl Canc Ctr, Res Inst, Div Multistep Carcinogenesis, Chuo Ku, Tokyo 104, Japan

[7] Natl Canc Ctr, Res Inst, Div Refractory Canc Res, Tokyo 104, Japan

[8] NCI, Human Carcinogenesis Lab, Ctr Canc Res, US Natl Inst Hlth, Bethesda, MD 20892 USA

[9] Natl Inst Occupat Hlth, Sect Toxicol, Dept Chem & Biol Working Environm, Oslo, Norway

[10] Mizuho Informat & Res Inst, Sci Solut Div, Chiyoda Ku, Tokyo, Japan

[11] StaGen, Stat Genet Anal Div, Taito Ku, Tokyo, Japan

[12] Natl Canc Ctr, Div Thorac Surg, Chuo Ku, Tokyo, Japan

[13] Natl Canc Ctr, Div Thorac Oncol, Chuo Ku, Tokyo, Japan

[14] Univ Tokyo, Bunkyo Ku, Canc Genom Project, Tokyo 113, Japan

来源：

NATURE MEDICINE | 2012年 / 18卷 / 03期

关键词：

CANCER; RET; IDENTIFICATION; THERAPY;

D O I：

10.1038/nm.2644

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We identified in-frame fusion transcripts of KIF5B (the kinesin family 5B gene) and the RET oncogene, which are present in 1-2% of lung adenocarcinomas (LADCs) from people from Japan and the United States, using whole-transcriptome sequencing. The KIF5B-RET fusion leads to aberrant activation of RET kinase and is considered to be a new driver mutation of LADC because it segregates from mutations or fusions in EGFR, KRAS, HER2 and ALK, and a RET tyrosine kinase inhibitor, vandetanib, suppresses the fusion-induced anchorage-independent growth activity of NIH3T3 cells.

引用

页码：375 / 377

页数：3

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