Lessons from case studies of metals: investigating exposure, bioavailability, and risk

被引：167

作者：

Caussy, D

Gochfeld, M

Gurzau, E

Neagu, C

Ruedel, H

机构：

[1] WHO, Dept Evidence & Informat Policy, Reg Off SE Asia, New Delhi 110002, India

[2] UMDNJ, Robert Wood Johnson Med Sch, Dept Environm & Community Med, Environm & Occupat Hlth Sci Inst, Piscataway, NJ 08854 USA

[3] Consortium Risk Evaluat Stakeholder Participat, Piscataway, NJ 08854 USA

[4] Ctr Environm Hlth, Cluj Napoca 3400, Romania

[5] Inst Publ Hlth, Bucharest 76256, Romania

[6] Fraunhofer Inst Umweltchem & Okotoxikol, D-57392 Schmallenberg, Germany

来源：

ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY | 2003年 / 56卷 / 01期

关键词：

bioavailability of heavy metals; outbreak investigation of metal poisoning; health risk paradigm; arsenic; mercury; lead; tin;

D O I：

10.1016/S0147-6513(03)00049-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Since metals are widely distributed in environmental matrices, humans are exposed to them by either anthropogenic activities or inadvertently by necessity. Selected metals: arsenic, mercury, iron, tin, lead and chromium were chosen on the basis of their economic and public health importance to illustrate the diversity of exposure pathways and differences in factors governing bioavailability. Bioavailability is central to the toxicity of metals and this is discussed from the health risk paradigm standpoint of risk assessment and risk management and the impacts of including or excluding bioavailability in such assessment. The lessons from the case studies of arsenic, mercury, tin and chromium provide a unified concept of methods that can be used in investigating and controlling outbreaks due to metal poisoning in other similar situations. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：45 / 51

页数：7