Pharmacological evidence for GABAergic and glutamatergic involvement in the convulsant and behavioral effects of glutaric acid

被引：47

作者：

Lima, TTF

Begnini, J

de Bastiani, J

Fialho, DB

Jurach, A

Ribeiro, MCP

Wajner, M

de Mello, CF ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Ctr Ciencias Nat & Exatas, Dept Quim, BR-97105900 Santa Maria, RS, Brazil

[2] Univ Fed Rio Grande Sul, Inst Ciencias Basicas Saude, Dept Bioquim, BR-90105900 Porto Alegre, RS, Brazil

来源：

BRAIN RESEARCH | 1998年 / 802卷 / 1-2期

关键词：

glutaric acid; organic acidemia; neurotoxicity; GABA; glutamate; seizure; turning behavior; striatum;

D O I：

10.1016/S0006-8993(98)00563-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of intrastriatal administration of glutaric acid (GTR), a metabolite that accumulates in glutaric acidemia type I (GA-I), on the behavior of adult male rats was investigated. After cannula placing, rats received unilateral intrastriatal injections of GTR buffered to pH 7.4 with NaOH or NaCl. GTR induced rotational behavior toward the contralateral side of injection and clonic convulsions in a dose-dependent manner. Rotational behavior was prevented by intrastriatal preadministration of DNQX and muscimol, but not by the preadministration of MK-801, Convulsions were prevented by intrastriatal preinjection of muscimol. This study provides evidence for a participation of glutamatergic non-NMDA and GABAergic mechanisms in the GTR-induced behavioral alterations. These findings may be of value in understanding the physiopathology of the neurological dysfunction in glutaric acidemia. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：55 / 60

页数：6