Role of Delta-like-4/Notch in the Formation and Wiring of the Lymphatic Network in Zebrafish

被引：103

作者：

Geudens, Ilse ^{[1
]}

Herpers, Robert ^{[2
,3
,4
]}

Hermans, Karlien ^{[1
]}

Segura, Inmaculada ^{[1
]}

de Almodovar, Carmen Ruiz ^{[1
]}

Bussmann, Jeroen ^{[2
,3
]}

De Smet, Frederik ^{[1
]}

Vandevelde, Wouter ^{[1
]}

Hogan, Benjamin M. ^{[2
,3
]}

Siekmann, Arndt ^{[5
]}

Claes, Filip ^{[1
]}

Moore, John C. ^{[5
]}

Pistocchi, Anna Silvia ^{[6
]}

Loges, Sonja ^{[1
]}

Mazzone, Massimiliano ^{[1
]}

Mariggi, Giovanni ^{[7
]}

Bruyere, Francoise ^{[8
]}

Cotelli, Franco ^{[6
]}

Kerjaschki, Dontscho ^{[9
]}

Noel, Agnes ^{[8
]}

Foidart, Jean-Michel ^{[8
]}

Gerhardt, Holger ^{[1
,7
]}

Ny, Annelii ^{[1
]}

Langenberg, Tobias ^{[1
]}

Lawson, Nathan D. ^{[5
]}

Duckers, Henricus J. ^{[4
]}

Schulte-Merker, Stefan ^{[2
,3
]}

Carmeliet, Peter ^{[1
]}

Dewerchin, Mieke ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, Vesalius Res Ctr, B-3000 Louvain, Belgium

[2] Hubrecht Inst KNAW, Utrecht, Netherlands

[3] Univ Med Ctr, Utrecht, Netherlands

[4] Erasmus Univ, Thoraxctr, Med Ctr, NL-3000 DR Rotterdam, Netherlands

[5] Univ Massachusetts, Sch Med, Program Gene Funct & Express, Worcester, MA USA

[6] Univ Milan, Dept Biol, Milan, Italy

[7] London Res Inst Canc Res, Vasc Biol Lab, London, England

[8] Univ Liege, Lab Tumor & Dev Biol, Liege, Belgium

[9] Med Univ Vienna, Clin Inst Pathol, Vienna, Austria

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2010年 / 30卷 / 09期

基金：

美国国家卫生研究院;

关键词：

vascular biology; gene silencing; lymphangiogenesis; notch signaling; zebrafish; EMBRYONIC VASCULAR DEVELOPMENT; ENDOTHELIAL-CELLS; IN-VIVO; NOTCH; ANGIOGENESIS; LYMPHANGIOGENESIS; MORPHOGENESIS; SPECIFICATION; ANGIOPOIETIN-1; MECHANISMS;

D O I：

10.1161/ATVBAHA.110.203034

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Objective-To study whether Notch signaling, which regulates cell fate decisions and vessel morphogenesis, controls lymphatic development. Methods and Results-In zebrafish embryos, sprouts from the axial vein have lymphangiogenic potential because they give rise to the first lymphatics. Knockdown of delta-like-4 (Dll4) or its receptors Notch-1b or Notch-6 in zebrafish impaired lymphangiogenesis. Dll4/Notch silencing reduced the number of sprouts producing the string of parchordal lymphangioblasts; instead, sprouts connecting to the intersomitic vessels were formed. At a later phase, Notch silencing impaired navigation of lymphatic intersomitic vessels along their arterial templates. Conclusion-These studies imply critical roles for Notch signaling in the formation and wiring of the lymphatic network. (Arterioscler Thromb Vasc Biol. 2010; 30: 1695-1702.)

引用

页码：1695 / 1702

页数：8

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