Functionalized bicyclo[3.3.0]octanes by enantioselective transannular desymmetrization

被引：30

作者：

Hodgson, DM ^{[1
]}

Cameron, ID ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Dyson Perrins Lab, Oxford OX1 3QY, England

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 03期

关键词：

D O I：

10.1021/ol006947n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Enantioselective alpha -deprotonation-rearrangement of achiral substituted cyclooctene oxides 7, 17, and 18 using organolithiums in the presence of (-)-sparteine (3) or (-)-alpha -isosparteine (4) gives the functionalized bicyclo[3.3.0]octen-2 ols 8, 19, and 20 in 56-72% yields and 83-89% ee's.

引用

页码：441 / 444

页数：4

共 34 条

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