Asymmetric rearrangement of N-Boc 7-azanorbornene oxide:: use of aryllithiums for enantioselective deprotonation

被引：25

作者：

Hodgson, DM

Maxwell, CR

Matthews, IR

机构：

[1] Univ Oxford, Dyson Perrins Lab, Dept Chem, Oxford OX1 3QY, England

[2] Zeneca Agrochem, Jealotts Hill Res Stn, Bracknell RG42 6ET, Berks, England

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 10期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0957-4166(99)00168-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective alpha-deprotonation-rearrangement of N-Boc 7-azanorbornene oxide 1 using aryllithiums in the presence of (-)-sparteine 4 or bisoxazolines 5a-c to give azanortricyclanol 2 in up to 87% ee is described. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1847 / 1850

页数：4

共 13 条

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