DNA-Based Applications in Nanobiotechnology

被引：42

作者：

Abu-Salah, Khalid M. ^{[1
]}

Ansari, Anees A.

Alrokayan, Salman A.

机构：

[1] King Saud Univ, King Abdullah Inst Nanotechnol, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2010年

关键词：

WALLED CARBON NANOTUBES; GENE DELIVERY; QUANTUM DOTS; IN-VITRO; BIOMEDICAL APPLICATIONS; SILICA NANOPARTICLES; ELECTRICAL DETECTION; GOLD NANOPARTICLES; PLASMID DNA; NANOTECHNOLOGY;

D O I：

10.1155/2010/715295

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biological molecules such as deoxyribonucleic acid ( DNA) have shown great potential in fabrication and construction of nanostructures and devices. The very properties that make DNA so effective as genetic material also make it a very suitable molecule for programmed self-assembly. The use of DNA to assemble metals or semiconducting particles has been extended to construct metallic nanowires and functionalized nanotubes. This paper highlights some important aspects of conjugating the unique physical properties of dots or wires with the remarkable recognition capabilities of DNA which could lead to miniaturizing biological electronics and optical devices, including biosensors and probes. Attempts to use DNA-based nanocarriers for gene delivery are discussed. In addition, the ecological advantages and risks of nanotechnology including DNA-based nanobiotechnology are evaluated.

引用

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