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RNA interference - The short answer
被引:72
作者
:
Bass, BL
论文数:
0
引用数:
0
h-index:
0
机构:
Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA
Bass, BL
机构
:
[1]
Univ Utah, Dept Biochem, Salt Lake City, UT 84132 USA
[2]
Univ Utah, Howard Hughes Med Inst, Salt Lake City, UT 84132 USA
来源
:
NATURE
|
2001年
/ 411卷
/ 6836期
关键词
:
D O I
:
10.1038/35078175
中图分类号
:
O [数理科学和化学];
P [天文学、地球科学];
Q [生物科学];
N [自然科学总论];
学科分类号
:
07 ;
0710 ;
09 ;
摘要
:
One way of seeing what a gene does is to block its messenger RNA and note the effects. New work should make the approach more broadly applicable.
引用
收藏
页码:428 / 429
页数:2
相关论文
共 14 条
[1]
Genome-wide RNAi
Barstead, R
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0
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0
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0
机构:
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
Barstead, R
[J].
CURRENT OPINION IN CHEMICAL BIOLOGY,
2001,
5
(01)
: 63
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66
[2]
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E
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0
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0
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0
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Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Bernstein, E
Caudy, AA
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0
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0
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0
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Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Caudy, AA
Hammond, SM
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Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Hammond, SM
Hannon, GJ
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0
引用数:
0
h-index:
0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Hannon, GJ
[J].
NATURE,
2001,
409
(6818)
: 363
-
366
[3]
dsRNA-mediated gene silencing in cultured Drosophila cells:: a tissue culture model for the analysis of RNA interference
Caplen, NJ
论文数:
0
引用数:
0
h-index:
0
机构:
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Caplen, NJ
Fleenor, J
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Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
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Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Fire, A
Morgan, RA
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0
引用数:
0
h-index:
0
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Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Morgan, RA
[J].
GENE,
2000,
252
(1-2)
: 95
-
105
[4]
RNA interference is mediated by 21-and 22-nucleotide RNAs
Elbashir, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Elbashir, SM
Lendeckel, W
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0
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0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Lendeckel, W
Tuschl, T
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Tuschl, T
[J].
GENES & DEVELOPMENT,
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15
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: 188
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200
[5]
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
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Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
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0
h-index:
0
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Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
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Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Yalcin, A
Weber, K
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Weber, K
Tuschl, T
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Tuschl, T
[J].
NATURE,
2001,
411
(6836)
: 494
-
498
[6]
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Fire, A
Xu, SQ
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0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Xu, SQ
Montgomery, MK
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Montgomery, MK
Kostas, SA
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0
引用数:
0
h-index:
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Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
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Driver, SE
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h-index:
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机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Driver, SE
Mello, CC
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Mello, CC
[J].
NATURE,
1998,
391
(6669)
: 806
-
811
[7]
HUNTER T, 1975, J BIOL CHEM, V250, P409
[8]
Functional genomics: The worm scores a knockout
Kim, SK
论文数:
0
引用数:
0
h-index:
0
机构:
Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
Kim, SK
[J].
CURRENT BIOLOGY,
2001,
11
(03)
: R85
-
R87
[9]
INTERACTIONS BETWEEN DOUBLE-STRANDED-RNA REGULATORS AND THE PROTEIN-KINASE DAI
MANCHE, L
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
MANCHE, L
GREEN, SR
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
GREEN, SR
SCHMEDT, C
论文数:
0
引用数:
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h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
SCHMEDT, C
MATHEWS, MB
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
MATHEWS, MB
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1992,
12
(11)
: 5238
-
5248
[10]
MINKS MA, 1979, J BIOL CHEM, V254, P180
←
1
2
→
共 14 条
[1]
Genome-wide RNAi
Barstead, R
论文数:
0
引用数:
0
h-index:
0
机构:
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA
Barstead, R
[J].
CURRENT OPINION IN CHEMICAL BIOLOGY,
2001,
5
(01)
: 63
-
66
[2]
Role for a bidentate ribonuclease in the initiation step of RNA interference
Bernstein, E
论文数:
0
引用数:
0
h-index:
0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Bernstein, E
Caudy, AA
论文数:
0
引用数:
0
h-index:
0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Caudy, AA
Hammond, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Hammond, SM
Hannon, GJ
论文数:
0
引用数:
0
h-index:
0
机构:
Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
Hannon, GJ
[J].
NATURE,
2001,
409
(6818)
: 363
-
366
[3]
dsRNA-mediated gene silencing in cultured Drosophila cells:: a tissue culture model for the analysis of RNA interference
Caplen, NJ
论文数:
0
引用数:
0
h-index:
0
机构:
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Caplen, NJ
Fleenor, J
论文数:
0
引用数:
0
h-index:
0
机构:
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Fleenor, J
Fire, A
论文数:
0
引用数:
0
h-index:
0
机构:
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Fire, A
Morgan, RA
论文数:
0
引用数:
0
h-index:
0
机构:
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Natl Human Genome Res Inst, Clin Gene Therapy Branch, NIH, Bethesda, MD 20892 USA
Morgan, RA
[J].
GENE,
2000,
252
(1-2)
: 95
-
105
[4]
RNA interference is mediated by 21-and 22-nucleotide RNAs
Elbashir, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Elbashir, SM
Lendeckel, W
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Lendeckel, W
Tuschl, T
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37077 Gottingen, Germany
Tuschl, T
[J].
GENES & DEVELOPMENT,
2001,
15
(02)
: 188
-
200
[5]
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
Elbashir, SM
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Elbashir, SM
Harborth, J
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Harborth, J
Lendeckel, W
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Lendeckel, W
Yalcin, A
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Yalcin, A
Weber, K
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Weber, K
Tuschl, T
论文数:
0
引用数:
0
h-index:
0
机构:
Max Planck Inst Biophys Chem, Dept Cellular Biochem, D-37033 Gottingen, Germany
Tuschl, T
[J].
NATURE,
2001,
411
(6836)
: 494
-
498
[6]
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
Fire, A
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Fire, A
Xu, SQ
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Xu, SQ
Montgomery, MK
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Montgomery, MK
Kostas, SA
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Kostas, SA
Driver, SE
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Driver, SE
Mello, CC
论文数:
0
引用数:
0
h-index:
0
机构:
Carnegie Inst Washington, Dept Embryol, Baltimore, MD 21210 USA
Mello, CC
[J].
NATURE,
1998,
391
(6669)
: 806
-
811
[7]
HUNTER T, 1975, J BIOL CHEM, V250, P409
[8]
Functional genomics: The worm scores a knockout
Kim, SK
论文数:
0
引用数:
0
h-index:
0
机构:
Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
Stanford Univ, Dept Dev Biol, Stanford, CA 94305 USA
Kim, SK
[J].
CURRENT BIOLOGY,
2001,
11
(03)
: R85
-
R87
[9]
INTERACTIONS BETWEEN DOUBLE-STRANDED-RNA REGULATORS AND THE PROTEIN-KINASE DAI
MANCHE, L
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
MANCHE, L
GREEN, SR
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
GREEN, SR
SCHMEDT, C
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
SCHMEDT, C
MATHEWS, MB
论文数:
0
引用数:
0
h-index:
0
机构:
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
COLD SPRING HARBOR LAB,POB 100,COLD SPRING HARBOR,NY 11724
MATHEWS, MB
[J].
MOLECULAR AND CELLULAR BIOLOGY,
1992,
12
(11)
: 5238
-
5248
[10]
MINKS MA, 1979, J BIOL CHEM, V254, P180
←
1
2
→