Strategies for optimized radiolabeling of nanoparticles for in vivo PET Imaging

被引：58

作者：

Sun, Guorong

Xu, Jinqi

Hagooly, Aviv

Rossin, Raffaella

Li, Zicheng

Moore, Dennis A.

Hawker, Craig J.

Welch, Michael J. ^{[1
]}

Wooley, Karen L.

机构：

[1] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Ctr Mat Innovat, St Louis, MO 63130 USA

[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA

[4] Mallinckrodt Inc, St Louis, MO 63134 USA

[5] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy to construct shell crosslinked nanoparticles has been developed, containing large numbers of effective DOTAlysines per particle (> 400) for Cu-64 radiolabeling. These Cu-64-complexed nanoparticles show impressive specific activities (ca. 400 mu Ci mu g(-1)), which suggests that they will serve as highly sensitive in vivo PET tracers at low administering doses.

引用

页码：3157 / +

页数：7

共 40 条

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