Strategies for optimized radiolabeling of nanoparticles for in vivo PET Imaging

被引：58

作者：

Sun, Guorong

Xu, Jinqi

Hagooly, Aviv

Rossin, Raffaella

Li, Zicheng

Moore, Dennis A.

Hawker, Craig J.

Welch, Michael J. ^{[1
]}

Wooley, Karen L.

机构：

[1] Washington Univ, Sch Med, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA

[2] Washington Univ, Ctr Mat Innovat, St Louis, MO 63130 USA

[3] Washington Univ, Dept Chem, St Louis, MO 63130 USA

[4] Mallinckrodt Inc, St Louis, MO 63134 USA

[5] Univ Calif Santa Barbara, Mat Res Lab, Santa Barbara, CA 93106 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 20期

关键词：

D O I：

10.1002/adma.200701973

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy to construct shell crosslinked nanoparticles has been developed, containing large numbers of effective DOTAlysines per particle (> 400) for Cu-64 radiolabeling. These Cu-64-complexed nanoparticles show impressive specific activities (ca. 400 mu Ci mu g(-1)), which suggests that they will serve as highly sensitive in vivo PET tracers at low administering doses.

引用

收藏

页码：3157 / +

页数：7

相关论文

共 40 条

[31] Receptor imaging in oncology by means of nuclear medicine: Current status [J].

Van Den Bossche, B ;

de Wiele, CV .

JOURNAL OF CLINICAL ONCOLOGY, 2004, 22 (17) :3593-3607

[32] Copper chelation chemistry and its role in copper radiopharmaceuticals [J].

Wadas, T. J. ;

Wong, E. H. ;

Weisman, G. R. ;

Anderson, C. J. .

CURRENT PHARMACEUTICAL DESIGN, 2007, 13 (01) :3-16

[33] Positron emission tomography: Applications in drug discovery and drug development [J].

Wang, JL ;

Maurer, L .

CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2005, 5 (11) :1053-1075

[34] Small animal PET: aspects of performance assessment [J].

Weber, S ;

Bauer, A .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2004, 31 (11) :1545-1555

[35]

Weber WA, 2006, J NUCL MED, V47, P735

[36] The potential of positron-emission tomography to study anticancer-drug resistance [J].

West, CML ;

Jones, T ;

Price, P .

NATURE REVIEWS CANCER, 2004, 4 (06) :457-469

[37]

Wooley KL, 2000, J POLYM SCI POL CHEM, V38, P1397, DOI 10.1002/(SICI)1099-0518(20000501)38:9<1397::AID-POLA1>3.0.CO

[38]

2-N

[39] Labeling of polymer nanostructures for medical imaging: Importance of cross-linking extent, spacer length, and charge density [J].

Xu, Jinqi ;

Sun, Guorong ;

Rossin, Raffaella ;

Hagooly, Aviv ;

Li, Zicheng ;

Fukukawa, Ken-ichi ;

Messmore, Benjamin W. ;

Moore, Dennis A. ;

Welch, Michael J. ;

Hawker, Craig J. ;

Wooley, Karen L. .

MACROMOLECULES, 2007, 40 (09) :2971-2973

[40] MULTIPLE MORPHOLOGIES OF CREW-CUT AGGREGATES OF POLYSTYRENE-B-POLY(ACRYLIC ACID) BLOCK-COPOLYMERS [J].

ZHANG, LF ;

EISENBERG, A .

SCIENCE, 1995, 268 (5218) :1728-1731

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