Moonlighting proteins: old proteins learning new tricks

被引:375
作者
Jeffery, CJ [1 ]
机构
[1] Univ Illinois, Dept Biol Sci, Mol Biol Lab, Chicago, IL 60607 USA
关键词
D O I
10.1016/S0168-9525(03)00167-7
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Recently, several laboratories identifying proteins involved in the complex processes of replication, transcription and tumor suppression found that the 'new' protein they discovered had another, previously identified, function. A single protein with multiple functions might seem surprising, but there are actually many cases of proteins that 'moonlight', or have more than one role in an organism. As well as adding to the number and types of proteins that are known to moonlight, these new examples add to our understanding of the potential importance of moonlighting proteins.
引用
收藏
页码:415 / 417
页数:3
相关论文
共 21 条
  • [1] Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma
    Astuti, D
    Latif, F
    Dallol, A
    Dahia, PLM
    Douglas, F
    George, E
    Sköldberg, F
    Husebye, ES
    Eng, C
    Maher, ER
    [J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (01) : 49 - 54
  • [2] GENETIC AND BIOCHEMICAL-CHARACTERIZATION OF THE BIRA GENE AND ITS PRODUCT - EVIDENCE FOR A DIRECT ROLE OF BIOTIN HOLOENZYME SYNTHETASE IN REPRESSION OF THE BIOTIN OPERON IN ESCHERICHIA-COLI
    BARKER, DF
    CAMPBELL, AM
    [J]. JOURNAL OF MOLECULAR BIOLOGY, 1981, 146 (04) : 469 - 492
  • [3] Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma
    Baysal, BE
    Ferrell, RE
    Willett-Brozick, JE
    Lawrence, EC
    Myssiorek, D
    Bosch, A
    van der Mey, A
    Taschner, PEM
    Rubinstein, WS
    Myers, EN
    Richard, CW
    Cornelisse, CJ
    Devilee, P
    Devlin, B
    [J]. SCIENCE, 2000, 287 (5454) : 848 - 851
  • [4] Ben-Yehuda S, 2000, GENETICS, V156, P1503
  • [5] Mismatch repair co-opted by hypermutation
    Cascalho, M
    Wong, J
    Steinberg, C
    Wabl, M
    [J]. SCIENCE, 1998, 279 (5354) : 1207 - 1210
  • [6] AUTOREGULATION OF HUMAN THYMIDYLATE SYNTHASE MESSENGER-RNA TRANSLATION BY THYMIDYLATE SYNTHASE
    CHU, E
    KOELLER, DM
    CASEY, JL
    DRAKE, JC
    CHABNER, BA
    ELWOOD, PC
    ZINN, S
    ALLEGRA, CJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (20) : 8977 - 8981
  • [7] Yeast ortholog of the Drosophila crooked neck protein promotes spliceosome assembly through stable U4/U6.U5 snRNP addition
    Chung, SY
    McLean, MR
    Rymond, BC
    [J]. RNA, 1999, 5 (08) : 1042 - 1054
  • [8] IDENTITY OF 4A-CARBINOLAMINE DEHYDRATASE, A COMPONENT OF THE PHENYLALANINE HYDROXYLATION SYSTEM, AND DCOH, A TRANSREGULATOR OF HOMEODOMAIN PROTEINS
    CITRON, BA
    DAVIS, MD
    MILSTIEN, S
    GUTIERREZ, J
    MENDEL, DB
    CRABTREE, GR
    KAUFMAN, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (24) : 11891 - 11894
  • [9] Characterization of the components of the putative mammalian sister chromatid cohesion complex
    Darwiche, N
    Freeman, LA
    Strunnikov, A
    [J]. GENE, 1999, 233 (1-2) : 39 - 47
  • [10] PUTA PROTEIN, A MEMBRANE-ASSOCIATED FLAVIN DEHYDROGENASE, ACTS AS A REDOX-DEPENDENT TRANSCRIPTIONAL REGULATOR
    DESPICER, PO
    MALOY, S
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (09) : 4295 - 4298