Activation of B lymphocytes: Integrating signals from CD19, CD22 and Fc gamma RIIb1

被引：47

作者：

Doody, GM

Dempsey, PW

Fearon, DT

机构：

[1] Wellcome Trust Immunology Unit, University of Cambridge, School of Clinical Medicine

来源：

CURRENT OPINION IN IMMUNOLOGY | 1996年 / 8卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0952-7915(96)80128-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three accessory membrane proteins, CD19, CD22 and Fc gamma RIIb1, alter signaling through membrane immunoglobulin of B cells by binding cytosolic proteins containing SH2 domains. Recent biochemical and genetic studies have shown that these receptors enable B cells to amplify responses to certain T-cell-dependent antigens (CD19), to restrict their response to T-cell zones of secondary lymphoid organs (CD22), and to dampen their response to antigens for which IgG is already available (Fc gamma RIIb1).

引用

页码：378 / 382

页数：5

共 47 条

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