Quantitative assessment of immediate cutaneous hypersensitivity in a model of genetic predisposition to atopy

被引:15
作者
Daser, A
Bätjer, N
Kölsch, U
Kötz, K
Schmeling, H
Schou, C
Renz, H
机构
[1] Humboldt Univ, Inst Clin Chem & Biochem, Virchow Clin, D-13353 Berlin, Germany
[2] ALK Abello, Horsholm, Denmark
关键词
immediate cutaneous hypersensitivity; candidate genes; inbred strains; segregation analysis; bonitur method;
D O I
10.1159/000024017
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Genetic predisposition and environmental factors modulate the expression of allergic phenotypes. The frequent allergic phenotype 'immediate cutaneous hypersensitivity' was established in mice as a model for atopy, Genetic dissection of this trait requires a robust procedure to assess the allergic phenotype. To this end, different mouse strains were immunized with birch pollen extract. Immediate cutaneous hypersensitivity reactions were induced through intradermal allergen exposure. Wheel formation was quantitated and expressed as a hypersensitivity score according to the bonitur method. This procedure identified A/J and C57BL/6 mice as high and low-responder strains, respectively. Crosses of A/J and C57BL/6 mice should allow the characterization of mendelian factors responsible for the two extreme phenotypes identified here.
引用
收藏
页码:239 / 243
页数:5
相关论文
共 11 条
[1]   Biology and genetics of atopic disease [J].
Casolaro, V ;
Georas, SN ;
Song, ZM ;
Ono, SJ .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (06) :796-803
[2]   Role and modulation of T-cell cytokines in allergy [J].
Daser, A ;
Meissner, N ;
Herz, U ;
Renz, H .
CURRENT OPINION IN IMMUNOLOGY, 1995, 7 (06) :762-770
[3]   The relevance of murine animal models to study the development of allergic bronchial asthma [J].
Herz, U ;
Lumpp, U ;
DaPalma, JC ;
Enssle, K ;
Takatsu, K ;
Schnoy, N ;
Daser, A ;
Kottgen, E ;
Wahn, U ;
Renz, H .
IMMUNOLOGY AND CELL BIOLOGY, 1996, 74 (02) :209-217
[4]  
Herz U, 1998, CLIN EXP ALLERGY, V28, P625
[5]   FURTHER CONTRIBUTIONS TO THE THEORY OF PAIRED COMPARISONS [J].
KENDALL, MG .
BIOMETRICS, 1955, 11 (01) :43-62
[6]   EFFECT OF COMBINATIONS OF INBRED STRAIN, ANTIGEN, AND ANTIGEN DOSE ON IMMUNE RESPONSIVENESS AND REAGIN PRODUCTION IN MOUSE - A POTENTIAL MOUSE MODEL FOR IMMUNE ASPECTS OF HUMAN ATOPIC ALLERGY [J].
LEVINE, BB ;
VAZ, NM .
INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1970, 39 (2-3) :156-&
[7]   PERIPHERAL LYMPHOID DEVELOPMENT AND FUNCTION IN TCR MUTANT MICE [J].
MOMBAERTS, P ;
MIZOGUCHI, E ;
LJUNGGREN, HG ;
IACOMINI, J ;
ISHIKAWA, H ;
WANG, L ;
GRUSBY, MJ ;
GLIMCHER, LH ;
WINN, HJ ;
BHAN, AK ;
TONEGAWA, S .
INTERNATIONAL IMMUNOLOGY, 1994, 6 (07) :1061-1070
[8]   Role of mast cells, eosinophils and IL-5 in the development of airway hyperresponsiveness in sensitized mice [J].
Nagai, H ;
Yamaguchi, S ;
Maeda, Y ;
Tanaka, H .
CLINICAL AND EXPERIMENTAL ALLERGY, 1996, 26 (06) :642-647
[9]   Susceptibility genes for allergy and asthma [J].
Ruffilli, A ;
Bonini, S .
ALLERGY, 1997, 52 (03) :256-273
[10]   DEVELOPMENT AND TRANSFER OF IMMEDIATE CUTANEOUS HYPERSENSITIVITY IN MICE EXPOSED TO AEROSOLIZED ANTIGEN [J].
SALOGA, J ;
RENZ, H ;
LACK, G ;
BRADLEY, KL ;
GREENSTEIN, JL ;
LARSEN, G ;
GELFAND, EW .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) :133-140