PERIPHERAL LYMPHOID DEVELOPMENT AND FUNCTION IN TCR MUTANT MICE

被引：90

作者：

MOMBAERTS, P

MIZOGUCHI, E

LJUNGGREN, HG

IACOMINI, J

ISHIKAWA, H

WANG, L

GRUSBY, MJ

GLIMCHER, LH

WINN, HJ

BHAN, AK

TONEGAWA, S

机构：

[1] MIT, CTR CANC RES, HOWARD HUGHES MED INST, CAMBRIDGE, MA 02139 USA

[2] MIT, CTR CANC RES, DEPT BIOL, CAMBRIDGE, MA 02139 USA

[3] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, DEPT PATHOL, BOSTON, MA 02114 USA

[4] KAROLINSKA INST, DEPT MICROBIOL & TUMOR BIOL, S-17177 STOCKHOLM, SWEDEN

[5] HARVARD UNIV, SCH PUBL HLTH, DEPT CANC BIOL, BOSTON, MA 02115 USA

[6] MASSACHUSETTS GEN HOSP, CTR STUDY INFLAMMATORY BOWEL DIS, BOSTON, MA 02114 USA

[7] HARVARD UNIV, SCH MED, DEPT MED, BOSTON, MA 02115 USA

[8] HARVARD UNIV, MASSACHUSETTS GEN HOSP, SCH MED, TRANSPLANTAT UNIT, BOSTON, MA 02114 USA

[9] NEW ENGLAND REG PRIMATE RES CTR, SOUTHBOROUGH, MA 01772 USA

来源：

INTERNATIONAL IMMUNOLOGY | 1994年 / 6卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENE TARGETING; LYMPHOCYTES; MUTANT MICE; T-CELLS;

D O I：

10.1093/intimm/6.7.1061

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe the development and function of the peripheral lymphoid system of mutant mice rendered deficient in either ce or gammadelta T cells via targeting of TCR genes in embryonic stem cells. in the spleen of alphabeta T cell-deficient mice, gammadelta T cells do not compensate in numbers for the lack of alphabeta T cells, but B cells do. Alphabeta T cell-deficient mice are unable to mount an antibody response to ovalbumin and do not reject skin allografts. Natural killer cell function is not impaired in any of the mutant mice. TCR mutant mice will prove useful in dissecting diffferential functions of alphabeta and gammadelta T cells in vivo.

引用

页码：1061 / 1070

页数：10

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