Novel forsterite/polycaprolactone nanocomposite scaffold for tissue engineering applications

被引：60

作者：

Diba, Mani ^{[1
]}

Fathi, M. H. ^{[1
]}

Kharaziha, M. ^{[1
]}

机构：

[1] Isfahan Univ Technol, Biomat Grp, Dept Mat Engn, Esfahan 8415683111, Iran

来源：

MATERIALS LETTERS | 2011年 / 65卷 / 12期

关键词：

Nanocomposites; Scaffold; Forsterite nanopowder; Porosity; COMPOSITE; FORSTERITE; FABRICATION;

D O I：

10.1016/j.matlet.2011.03.047

中图分类号：

T [工业技术];

学科分类号：

120111 [工业工程];

摘要：

Novel highly porous nanocomposite scaffolds consisting of polycaprolactone (PCL) and forsterite nanopowder were prepared by a solvent-casting/particle-leaching method. In addition, the effects of forsterite nanopowder contents on the structure of the scaffolds were investigated to provide an appropriate composite for bone regenerative medicine. Results showed that the scaffolds exhibited high porosity (up to 92%) with open pores of 100-300 mu m average diameters. This porosity increased with decreasing forsterite nanopowder content. In addition, the pore walls contained numerous micropores. Microstructure studies showed that the pores were well distributed throughout the structures. Furthermore, the bioactive forsterite nanoparticles were homogenously distributed within the PCL matrix of the scaffolds, which contained up to 30 wt.% forsterite nanopowder. This porous structure with micropores provides the properties required for bone tissue engineering applications. (C) 2011 Elsevier B.V. All rights reserved,

引用

页码：1931 / 1934

页数：4

共 21 条

[1]

An electrospun triphasic nanofibrous scaffold for bone tissue engineering [J].