Molecular aspects of osteoclast function

被引:48
作者
Hall, TJ [1 ]
Chambers, TJ [1 ]
机构
[1] ST GEORGE HOSP, SCH MED, DEPT HISTOPATHOL, LONDON SW17 0RE, ENGLAND
关键词
osteoclasts; bone resorption; molecular mechanisms; regulation;
D O I
10.1007/BF02263497
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
In this article we have overviewed recent important advances in understanding the molecular mechanisms involved in osteoclastic bone resorption. Specifically, new findings relating to osteoclast activation and the process of bone resorption are reviewed and a current overall model of how osteoclasts resorb bone is presented. Controversial research topics concerning the regulation of osteoclast activity are also critically discussed.
引用
收藏
页码:1 / 9
页数:9
相关论文
共 115 条
[11]   ISOLATED OSTEOCLASTS RESORB THE ORGANIC AND INORGANIC COMPONENTS OF BONE [J].
BLAIR, HC ;
KAHN, AJ ;
CROUCH, EC ;
JEFFREY, JJ ;
TEITELBAUM, SL .
JOURNAL OF CELL BIOLOGY, 1986, 102 (04) :1164-1172
[12]  
BOLEN JB, 1993, ONCOGENE, V8, P2025
[13]   HISTOMORPHOMETRIC AND IMMUNOCYTOCHEMICAL STUDIES OF SRC-RELATED OSTEOPETROSIS [J].
BOYCE, BF ;
CHEN, H ;
SORIANO, P ;
MUNDY, GR .
BONE, 1993, 14 (03) :335-340
[14]   REQUIREMENT OF PP60C-SRC EXPRESSION FOR OSTEOCLASTS TO FORM RUFFLED BORDERS AND RESORB BONE IN MICE [J].
BOYCE, BF ;
YONEDA, T ;
LOWE, C ;
SORIANO, P ;
MUNDY, GR .
JOURNAL OF CLINICAL INVESTIGATION, 1992, 90 (04) :1622-1627
[15]   BIDIRECTIONAL REGULATION OF OSTEOCLAST FUNCTION BY NITRIC-OXIDE SYNTHASE ISOFORMS [J].
BRANDI, ML ;
HUKKANEN, M ;
UMEDA, T ;
MORADIBIDHENDI, N ;
BIANCHI, S ;
GROSS, SS ;
POLAK, JM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2954-2958
[16]   CLONING AND CHARACTERIZATION OF AN EXTRACELLULAR CA2+-SENSING RECEPTOR FROM BOVINE PARATHYROID [J].
BROWN, EM ;
GAMBA, G ;
RICCARDI, D ;
LOMBARDI, M ;
BUTTERS, R ;
KIFOR, O ;
SUN, A ;
HEDIGER, MA ;
LYTTON, J ;
HEBERT, SC .
NATURE, 1993, 366 (6455) :575-580
[17]   OXIDATIVE STRESS AS A MEDIATOR OF APOPTOSIS [J].
BUTTKE, TM ;
SANDSTROM, PA .
IMMUNOLOGY TODAY, 1994, 15 (01) :7-10
[18]  
CHAMBERS TJ, 1991, VITAM HORM, V46, P41
[19]  
CHAMBERS TJ, 1984, J CELL SCI, V66, P383
[20]  
CHAMBERS TJ, 1985, J CELL SCI, V76, P155