Asthma in Hispanics

被引:101
作者
Hunninghake, GM
Weiss, ST
Celedón, JC
机构
[1] Harvard Univ, Sch Med, Channing Lab, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Resp Disorders Program, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Dept Med,Div Pulm & Crit Care Med, Boston, MA 02115 USA
关键词
asthma; genetics; Hispanics; risk factors;
D O I
10.1164/rccm.200508-1232SO
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Hispanic individuals trace their ancestry to countries that were previously under Spanish rule, including Mexico, large parts of Central and South America, and some Caribbean islands. Most-but not all-Hispanics have variable proportions of European, Amerindian, and African ancestry. Hispanics are diverse with regard to many factors, including racial ancestry, country of origin, area of residence, socioeconomic status, education, and access to health care. Recent findings suggest that there is marked variation in the prevalence, morbidity, and mortality of asthma in Hispanics in the United States and in Hispanic America. The reasons for differences in asthma and asthma morbidity among and within Hispanic subgroups are poorly understood but are likely due to the interaction between yet-unidentified genetic variants and other factors, including environmental tobacco smoke exposure, obesity, allergen exposure, and availability of health care. Barriers to optimal management of asthma in Hispanics in the United States and in Hispanic America include inadequate access to health care, suboptimal use of antiinflammatory medications, and lack of reference values for spirometric measures of lung function in many subgroups (e.g., Puerto Ricans). Future studies of asthma in Hispanics should include large samples of subgroups that are well characterized with regard to self-reported ethnicity, country of origin, place of birth, area of residence, and indicators of socioeconomic status. Because Hispanics are disproportionately represented among the poor in the United States, implementation of adequate access to health care and social reforms (e.g., improving housing conditions) would likely have a major impact on reducing asthma morbidity in this population.
引用
收藏
页码:143 / 163
页数:21
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