Quorum sensing in Vibrio harveyi:: probing the specificity of the LuxP binding site

被引：41

作者：

Lowery, CA ^{[1
]}

McKenzie, KM ^{[1
]}

Qi, LW ^{[1
]}

Meijler, MM ^{[1
]}

Janda, KD ^{[1
]}

机构：

[1] Scripps Res Inst & Skaggs, Inst Biol Chem, Dept Chem, La Jolla, CA 92037 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 09期

关键词：

quorum sensing; bacterial communication; quorum sensing analogs;

D O I：

10.1016/j.bmcl.2005.02.069

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quorum sensing activity was investigated in the bacterium Vibrio harveyi using a series of both natural and nonnatural analogs of DPD, the penultimate precursor to autoinducer AI-2. The progression of molecules that were both synthesized and investigated includes enantiomeric variants, carbon-chain extension, and hydroxyl -functional group addition/deletions of DPD. The compilation of these studies reveals a binding cleft that can accommodate a number of different structural variants of DPD, albeit with invariably lower activities. (c) 2005 Published by Elsevier Ltd.

引用

页码：2395 / 2398

页数：4

共 19 条

[1] One-step synthesis of laurencione [J].

Aelterman, W ;

DeKimpe, N ;

Kalinin, V .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04) :385-386

[2] Synthesis of LuxS inhibitors targeting bacterial cell-cell communication [J].

Alfaro, JF ;

Zhang, T ;

Wynn, DP ;

Karschner, EL ;

Zhou, ZS .

ORGANIC LETTERS, 2004, 6 (18) :3043-3046

[3] MULTIPLE SIGNALING SYSTEMS CONTROLLING EXPRESSION OF LUMINESCENCE IN VIBRIO-HARVEYI - SEQUENCE AND FUNCTION OF GENES ENCODING A 2ND SENSORY PATHWAY [J].

BASSLER, BL ;

WRIGHT, M ;

SILVERMAN, MR .

MOLECULAR MICROBIOLOGY, 1994, 13 (02) :273-286

[4] Structural identification of a bacterial quorum-sensing signal containing boron [J].

Chen, X ;

Schauder, S ;

Potier, N ;

Van Dorsselaer, A ;

Pelczer, I ;

Bassler, BL ;

Hughson, FM .

NATURE, 2002, 415 (6871) :545-549

[5] BACTERIAL BIOLUMINESCENCE - ISOLATION AND GENETIC-ANALYSIS OF FUNCTIONS FROM VIBRIO FISCHERI [J].

ENGEBRECHT, J ;

NEALSON, K ;

SILVERMAN, M .

CELL, 1983, 32 (03) :773-781

[6] QUORUM SENSING IN BACTERIA - THE LUXR-LUXI FAMILY OF CELL DENSITY-RESPONSIVE TRANSCRIPTIONAL REGULATORS [J].

FUQUA, WC ;

WINANS, SC ;

GREENBERG, EP .

JOURNAL OF BACTERIOLOGY, 1994, 176 (02) :269-275

[7] Synthesis of 1-deoxy-D-erythro-hexo-2,3-diulose, a major hexose Maillard intermediate [J].

Glomb, MA ;

Pfahler, C .

CARBOHYDRATE RESEARCH, 2000, 329 (03) :515-523

[8] BACTERIAL BIOLUMINESCENCE [J].

HASTINGS, JW ;

NEALSON, KH .

ANNUAL REVIEW OF MICROBIOLOGY, 1977, 31 :549-595

[9] Chemical signaling among bacteria and its inhibition [J].

Lyon, GJ ;

Muir, TW .

CHEMISTRY & BIOLOGY, 2003, 10 (11) :1007-1021

[10] Synthesis and biological validation of a ubiquitous quorum-sensing molecule [J].

Meijler, MM ;

Hom, LG ;

Kaufmann, GF ;

McKenzie, KM ;

Sun, CZ ;

Moss, JA ;

Matsushita, M ;

Janda, KD .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2004, 43 (16) :2106-2108

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