Sirtuins for healthy neurons

被引：32

作者：

Sinclair, D ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA

来源：

NATURE GENETICS | 2005年 / 37卷 / 04期

关键词：

D O I：

10.1038/ng0405-339

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sir2 deacetylases are believed to promote the survival and longevity of organisms during times of adversity. A new study shows that activation of Sir2 by small molecules called sirtuin-activating compounds increases neuronal survival in two different models of Huntington disease, possibly opening new avenues for treatment.

引用

页码：339 / 340

页数：2

共 13 条

[1]

Aggarwal BB, 2004, ANTICANCER RES, V24, P2783

[2] Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration [J].

Araki, T ;

Sasaki, Y ;

Milbrandt, J .

SCIENCE, 2004, 305 (5686) :1010-1013

[3] The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms [J].

Kaeberlein, M ;

McVey, M ;

Guarente, L .

GENES & DEVELOPMENT, 1999, 13 (19) :2570-2580

[4] Small molecules that regulate lifespan: evidence for xenohormesis [J].

Lamming, DW ;

Wood, JG ;

Sinclair, DA .

MOLECULAR MICROBIOLOGY, 2004, 53 (04) :1003-1009

[5] Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons [J].

Parker, JA ;

Arango, M ;

Abderrahmane, S ;

Lambert, E ;

Tourette, C ;

Catoire, H ;

Néri, C .

NATURE GENETICS, 2005, 37 (04) :349-350

[6]

Picard F, 2004, NATURE, V429, P771, DOI 10.1038/nature02583

[7] Sir2 mediates longevity in the fly through a pathway related to calorie restriction [J].

Rogina, B ;

Helfand, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (45) :15998-16003

[8] Extrachromosomal rDNA circles - A cause of aging in yeast [J].

Sinclair, DA ;

Guarente, L .

CELL, 1997, 91 (07) :1033-1042

[9] Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans [J].

Tissenbaum, HA ;

Guarente, L .

NATURE, 2001, 410 (6825) :227-230

[10] High absorption but very low bioavailability of oral resveratrol in humans [J].

Walle, T ;

Hsieh, F ;

DeLegge, MH ;

Oatis, JE ;

Walle, UK .

DRUG METABOLISM AND DISPOSITION, 2004, 32 (12) :1377-1382

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