Traps to catch unwary oncogenes

被引：101

作者：

Hueber, AO ^{[1
]}

Evan, GI ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Biochem Cell Nucleus Lab, London WC2A 3PX, England

来源：

TRENDS IN GENETICS | 1998年 / 14卷 / 09期

关键词：

D O I：

10.1016/S0168-9525(98)01520-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The MYC proto-oncogene has long been implicated in the control of normal cell growth and its deregulation is associated with the development of neoplasia. The MYC protein has a well-established role as a component of signal-transduction pathways promoting both proliferation and apoptosis. Because signalling pathways that drive cell death and cell proliferation are so tightly coupled, a synergy between genetic lesions leading to suppression of cell death and those promoting cell proliferation is observed during carcinogenesis. We discuss such synergy with respect to the cooperating oncogenes MYC, RAS and BCL2.

引用

页码：364 / 367

页数：4

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