Ectopic Expression of Germline Genes Drives Malignant Brain Tumor Growth in Drosophila

被引：211

作者：

Janic, Ana ^{[1
]}

Mendizabal, Leire ^{[1
]}

Llamazares, Salud ^{[1
]}

Rossell, David ^{[2
]}

Gonzalez, Cayetano ^{[1
,3
]}

机构：

[1] PCB, IRB Barcelona, Cell Div Grp, Barcelona, Spain

[2] PCB, IRB Barcelona, Bioinformat & Biostat Unit, Barcelona, Spain

[3] Passeig Lluis Co 23, ICREA, Barcelona, Spain

来源：

SCIENCE | 2010年 / 330卷 / 6012期

关键词：

TRANSCRIPTIONAL REPRESSOR; CANCER/TESTIS ANTIGENS; STEM-CELLS; COMPLEX; PROTEIN; IDENTIFICATION; MELANOGASTER; INTERACTS; DIVISION; MUTANTS;

D O I：

10.1126/science.1195481

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Model organisms such as the fruit fly Drosophila melanogaster can help to elucidate the molecular basis of complex diseases such as cancer. Mutations in the Drosophila gene lethal (3) malignant brain tumor cause malignant growth in the larval brain. Here we show that l(3)mbt tumors exhibited a soma-to-germline transformation through the ectopic expression of genes normally required for germline stemness, fitness, or longevity. Orthologs of some of these genes were also expressed in human somatic tumors. In addition, inactivation of any of the germline genes nanos, vasa, piwi, or aubergine suppressed l(3) mbt malignant growth. Our results demonstrate that germline traits are necessary for tumor growth in this Drosophila model and suggest that inactivation of germline genes might have tumor-suppressing effects in other species.

引用

页码：1824 / 1827

页数：4

共 32 条

[1] The human L(3)MBT polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6) [J].