Spindle orientation, asymmetric division and tumour suppression in Drosophila stem cells

被引：154

作者：

Gonzalez, Cayetano

机构：

[1] IRB, Cell Div Grp, Barcelona, Spain

[2] ICREA, Barcelona, Spain

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 06期

关键词：

D O I：

10.1038/nrg2103

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent genetic studies in flies have added further support to an increasing body of evidence that suggests that stem cells might be the cell-of-origin of certain tumours. Malfunction of the mechanisms that control the division of stem cells and the developmental fate of the two resulting daughters could be one of the initial events that steers cells into malignant transformation. These studies suggest a role for controlled spindle orientation in suppressing stem-cell overgrowth. In parallel, the machinery that drives asymmetry in stem cells has been further characterized, identifying new components and uncovering the unique, highly sophisticated behaviour of centrosomes in these cells.

引用

收藏

页码：462 / 472

页数：11

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