Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.