Multifunctional nanoparticles for photothermally controlled drug delivery and magnetic resonance imaging enhancement

被引：127

作者：

Park, Huiyul ^{[1
]}

Yang, Jaemoon ^{[2
]}

Seo, Sungbaek ^{[2
]}

Kim, Kyujung ^{[3
]}

Suh, Jinsuk ^{[4
]}

Kim, Donghyun ^{[3
]}

Haam, Seungjoo ^{[2
]}

Yoo, Kyung-Hwa ^{[1
]}

机构：

[1] Yonsei Univ, Dept Phys, Seoul 120742, South Korea

[2] Yonsei Univ, Dept Chem Engn, Seoul 120742, South Korea

[3] Yonsei Univ, Dept Elect & Elect Engn, Seoul 120742, South Korea

[4] Yonsei Univ, Coll Med, Dept Radiol, Seoul 120752, South Korea

来源：

SMALL | 2008年 / 4卷 / 02期

关键词：

contrast enhancement; core/shell materials; encapsulation; gold; magnetic resonance imaging;

D O I：

10.1002/smll.200700807

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The use of biodegradable polymer-metal multilayer half-shell nanoparticles (H-S NPs) for photothermally controlled drug delivery and magnetic resonance imaging enhancement, was analyzed. The drug is encapsulated within biocompatible and biodegradable polymer nanoparticles, where metal multilayers are deposited on these nanoparticles. The absorption spectra was measured of the nanoparticle using a UV-visible/NIR spectrometer for poly(lactic-co-glycolic acid) (PLGA)-Au H-S NPs. The optical and photothermal conversion properties of rhodamine-loaded PLGA-Au H-S NPs with PLGA nanoparticles were examined. Rhodamine release was monitored from PLGA nanoparticles using total internal reflection fluorescence microscopy (TIRFM). Results show that these nanoparticles can efficiently achieve their selective cell target.

引用

页码：192 / 196

页数：5

共 20 条

[11] Development of a T1 contrast agent for magnetic resonance imaging using MnO nanoparticles [J].