Long QT syndrome: from channels to cardiac arrhythmias

被引：208

作者：

Moss, AJ

Kass, RS

机构：

[1] Univ Rochester, Med Ctr,Dept Med, Sch Med & Dent, Heart Res Followup Program, Rochester, NY 14642 USA

[2] Columbia Univ, Med Ctr, Dept Pharmacol, New York, NY USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 08期

关键词：

D O I：

10.1172/JCI25537

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative interactions between clinical and basic scientists. Our understanding of the mechanisms that control the critical plateau and repolarization phases of the human ventricular action potential has been raised to new levels through these studies, which have clarified the manner in which both potassium and sodium channels regulate this critical period of electrical activity.

引用

收藏

页码：2018 / 2024

页数：7

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