Conservation of protein-protein interactions -: lessons from ascomycota

被引：32

作者：

Pagel, P

Mewes, HW

Frishman, D

机构：

[1] GSF, Natl Res Ctr Environm & Hlth, Inst Bioinformat, D-85764 Neuherberg, Germany

[2] Tech Univ Munich, Dept Genome Oriented Bioinformat, Wissensch Zentrum Weihenstephan, D-85350 Freising Weihenstephan, Germany

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 02期

关键词：

D O I：

10.1016/j.tig.2003.12.007

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Interacting proteins from Saccharomyces cerevisiae are evolutionarily conserved and their likelihood of having an ortholog in other ascomycota species correlates with the number of interaction partners. Moreover, interacting proteins show a clear preference to be conserved as a pair, indicating that nature maintains selection pressure on the interaction links between proteins. The conservation of interacting protein pairs between different organisms does not exhibit any bias with respect to protein functional roles.

引用

页码：72 / 76

页数：5

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