Treadmill exercise enhances passive avoidance learning in rats: The role of down-regulated serotonin system in the limbic system

被引：53

作者：

Chen, Hsiun-Ing ^{[1
,2
]}

Lin, Li-Chun ^{[1
]}

Yu, Lung ^{[3
]}

Liu, Yu-Fan ^{[2
]}

Kuo, Yu-Min ^{[2
,4
]}

Huang, A-Min ^{[1
,2
]}

Chuang, Jih-Ing ^{[1
,2
]}

Wu, Fong-Sen ^{[1
,2
]}

Liao, Pao-Chi ^{[5
]}

Jen, Chauying J. ^{[1
,2
]}

机构：

[1] Natl Cheng Kung Univ, Coll Med, Dept Physiol, Tainan 701, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Inst Basic Med Sci, Tainan 701, Taiwan

[3] Natl Cheng Kung Univ, Coll Med, Inst Behav Med, Tainan 701, Taiwan

[4] Natl Cheng Kung Univ, Coll Med, Dept Cell Biol & Anat, Tainan 701, Taiwan

[5] Natl Cheng Kung Univ, Coll Med, Dept Environm & Occupat Hlth, Tainan 701, Taiwan

来源：

NEUROBIOLOGY OF LEARNING AND MEMORY | 2008年 / 89卷 / 04期

关键词：

one-trial passive avoidance task; 5-HT; 5-HT1A receptor; amygdala; hippocampus;

D O I：

10.1016/j.nlm.2007.08.004

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

While serotonin (5-HT) may impair learning and memory, exercise has been reported to improve them. Whether chronic exercise can facilitate fear memory via regulating the serotonin system is unknown. We examined the effects of 4-week treadmill exercise training on levels of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), the protein expression of its receptor 5-HT1A and transporter in the amygdala, hippocampus and prefrontal cortex of male Sprague-Dawley rats. Our results demonstrated that treadmill exercise (1) improved the passive avoidance learning performance; (2) decreased the 5-HT level in the hippocampus; (3) decreased the expression of 5-HTIA receptor in the amygdala without altering the transporter expression. Moreover, pretreatment with 0.1 mg/kg 8-hydroxy-di-n-propylamino tetralin, a selective 5-HT1A receptor agonist, impaired the passive avoidance performance and completely abolished the exercise-enhanced fear memory. Our results suggest that down-regulation of the 5-HT system in the limbic system, i.e., the reduction of the hippocampus 5-HT content and the amygdala 5-HTIA receptor expression, may be involved in the exercise-enhanced fear memory. (C) 2007 Elsevier Inc. All rights reserved.

引用

页码：489 / 496

页数：8

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