Functional MRI and motor behavioral changes obtained with constraint-induced movement therapy in chronic stroke

被引:61
作者
Kononen, M. [1 ,2 ]
Tarkka, I. M. [3 ]
Niskanen, E. [2 ,4 ]
Pihlajamaki, M. [5 ,6 ]
Mervaala, E. [1 ,7 ]
Pitkanen, K. [8 ]
Vanninen, R. [2 ,9 ]
机构
[1] Kuopio Univ Hosp, Dept Clin Neurophysiol, FI-70211 Kuopio, Finland
[2] Kuopio Univ Hosp, Dept Clin Radiol, FI-70211 Kuopio, Finland
[3] Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla, Finland
[4] Univ Eastern Finland, Dept Appl Phys, Kuopio, Finland
[5] Kuopio Univ Hosp, Dept Neurol, FI-70211 Kuopio, Finland
[6] Univ Eastern Finland, Dept Neurol, Sch Med, Kuopio, Finland
[7] Univ Eastern Finland, Sch Med, Dept Clin Neurophysiol, Kuopio, Finland
[8] Brain Res & Rehabil Ctr Neuron, Kuopio, Finland
[9] Univ Eastern Finland, Sch Med, Inst Clin Med, Dept Clin Radiol, Kuopio, Finland
关键词
constraint-induced movement therapy; functional MRI; plasticity; rehabilitation; stroke; transcranial magnetic stimulation; CORTICAL REORGANIZATION; REHABILITATIVE THERAPY; FMRI; METAANALYSIS; ACTIVATION; RECOVERY; TRIALS; CORTEX; BRAIN; TMS;
D O I
10.1111/j.1468-1331.2011.03572.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Background: The clinical benefits of intensive stroke rehabilitation vary individually. We used multimodal functional imaging to assess the relationship of clinical gain and imaging changes in patients with chronic stroke whose voluntary motor control improved after constraint-induced movement therapy (CIMT). Methods: Eleven patients (37.6 +/- 36.8 months from stroke) were studied by functional MRI (fMRI), transcranial magnetic stimulation (TMS), and behavioral assessment of hand motor control (Wolf Motor Function Test) before and after 2 weeks of CIMT. Individual and group-level changes in imaging and behavioral parameters were investigated. Results: Increase in fMRI activation in the sensorimotor areas was greater amongst those subjects who had poor hand motor behavior before therapy and/or whose motor behavior improved notably because of therapy than amongst subjects with relatively good motor behavior already before therapy. The magnitude of CIMT-induced changes in task-relatedfMRIactivation differed between lesioned and non-lesioned hemispheres, and the fMRI laterality index was different for paretic and non-paretic hand tasks. The corticospinal conduction time in TMS was significantly decreased after CIM therapy. Conclusions: Alterations in sensorimotor cortical activations (fMRI) and corticospinal conductivity (TMS) were observed after intensive rehabilitation in patients with chronic stroke. Activation and functional changes in fMRI and TMS correlated significantly with the degree of clinical improvement in hand motor behavior. The present data advance the understanding of the functional underpinnings of motor recovery, which may be obtained even years after the stroke.
引用
收藏
页码:578 / 586
页数:9
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