Regulation of pulmonary endothelial barrier function by kinases

被引：53

作者：

Barabutis, Nektarios ^{[1
]}

Verin, Alexander ^{[2
]}

Catravas, John D. ^{[1
,3
]}

机构：

[1] Old Dominion Univ, Frank Reidy Res Ctr Bioelect, Norfolk, VA 23508 USA

[2] Augusta Univ, Vasc Biol Ctr, Augusta, GA USA

[3] Old Dominion Univ, Coll Hlth Sci, Sch Med Diagnost & Translat Sci, Norfolk, VA USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2016年 / 311卷 / 05期

关键词：

barrier function; endothelium; kinases; lung; permeability; LIGHT-CHAIN KINASE; FOCAL ADHESION KINASE; ACTIVATED PROTEIN-KINASE; ACTIN-DEPOLYMERIZING FACTOR; RHO-ASSOCIATED KINASE; NITRIC-OXIDE SYNTHASE; P38 MAPK ACTIVATION; NF-KAPPA-B; TYROSINE PHOSPHORYLATION; SMOOTH-MUSCLE;

D O I：

10.1152/ajplung.00233.2016

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

引用

页码：L832 / L845

页数：14

共 280 条

[1]

Vascular endothelial growth factor stimulates tyrosine phosphorylation and recruitment to new focal adhesions of focal adhesion kinase and paxillin in endothelial cells [J].

Abedi, H ;

Zachary, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (24) :15442-15451

[2]

Protein kinase A intersects Src signaling in membrane microdomains [J].

Abrahamsen, H ;

Vang, T ;

Taskén, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17170-17177

[3]

Src mediates stimulation by vascular endothelial growth factor of the phosphorylation of focal adhesion kinase at tyrosine 861, and migration and anti-apoptosis in endothelial cells [J].

Abu-Ghazaleh, R ;

Kabir, J ;

Jia, H ;

Lobo, M ;

Zachary, I .

BIOCHEMICAL JOURNAL, 2001, 360 :255-264

[4]

Regulation of Endothelial Adherens Junctions by Tyrosine Phosphorylation [J].

Adam, Alejandro Pablo .

MEDIATORS OF INFLAMMATION, 2015, 2015

[5]

Sphingosine-1-phosphate modulation of basal permeability and acute inflammatory responses in rat venular microvessels [J].

Adamson, Roger H. ;

Sarai, Rupinder K. ;

Altangerel, Ariungerel ;

Thirkill, Twanda L. ;

Clark, Joyce F. ;

Curry, Fitz-Roy E. .

CARDIOVASCULAR RESEARCH, 2010, 88 (02) :344-351

[6]

REACTIVATION OF PHOSPHORYLATED ACTIN DEPOLYMERIZING FACTOR AND IDENTIFICATION OF THE REGULATORY SITE [J].

AGNEW, BJ ;

MINAMIDE, LS ;

BAMBURG, JR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (29) :17582-17587

[7]

Involvement of Protein Kinase C-δ in Vascular Permeability in Acute Lung Injury [J].

Ahn, Jong J. ;

Jung, Jong P. ;

Park, Soon E. ;

Lee, Minhyun ;

Kwon, Byungsuk ;

Cho, Hong R. .

IMMUNE NETWORK, 2015, 15 (04) :206-211

[8]

Aitken Alastair, 2003, Methods Mol Biol, V211, P465

[9]

Inflammatory mediators induce sequestration of VE-cadherin in cultured human endothelial cells [J].

Alexander, JS ;

Alexander, BC ;

Eppihimer, LA ;

Goodyear, N ;

Haque, R ;

Davis, CP ;

Kalogeris, TJ ;

Carden, CL ;

Zhu, YN ;

Kevil, CG .

INFLAMMATION, 2000, 24 (02) :99-113

[10]

The role of cadherin endocytosis in endothelial barrier regulation: Involvement of protein kinase C and actin-cadherin interactions [J].

Alexander, JS ;

Jackson, SA ;

Chaney, E ;

Kevil, CG ;

Haselton, FR .

INFLAMMATION, 1998, 22 (04) :419-433

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