Regulation of pulmonary endothelial barrier function by kinases

被引：53

作者：

Barabutis, Nektarios ^{[1
]}

Verin, Alexander ^{[2
]}

Catravas, John D. ^{[1
,3
]}

机构：

[1] Old Dominion Univ, Frank Reidy Res Ctr Bioelect, Norfolk, VA 23508 USA

[2] Augusta Univ, Vasc Biol Ctr, Augusta, GA USA

[3] Old Dominion Univ, Coll Hlth Sci, Sch Med Diagnost & Translat Sci, Norfolk, VA USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2016年 / 311卷 / 05期

关键词：

barrier function; endothelium; kinases; lung; permeability; LIGHT-CHAIN KINASE; FOCAL ADHESION KINASE; ACTIVATED PROTEIN-KINASE; ACTIN-DEPOLYMERIZING FACTOR; RHO-ASSOCIATED KINASE; NITRIC-OXIDE SYNTHASE; P38 MAPK ACTIVATION; NF-KAPPA-B; TYROSINE PHOSPHORYLATION; SMOOTH-MUSCLE;

D O I：

10.1152/ajplung.00233.2016

中图分类号：

Q4 [生理学];

学科分类号：

071003 [生理学];

摘要：

The pulmonary endothelium is the target of continuous physiological and pathological stimuli that affect its crucial barrier function. The regulation, defense, and repair of endothelial barrier function require complex biochemical processes. This review examines the role of endothelial phosphorylating enzymes, kinases, a class with profound, interdigitating influences on endothelial permeability and lung function.

引用

页码：L832 / L845

页数：14

共 280 条

[31]

Molecular mechanisms of thrombin-induced endothelial cell permeability [J].

Bogatcheva, NV ;

Garcia, JGN ;

Verin, AD .

BIOCHEMISTRY-MOSCOW, 2002, 67 (01) :75-84

[32]

Protein kinase Cμ regulation of the JNK pathway is triggered via phosphoinositide-dependent kinase 1 and protein kinase Cε [J].

Brändlin, I ;

Eiseler, T ;

Salowsky, R ;

Johannes, FJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :45451-45457

[33]

IDENTIFICATION OF A TRANSFORMATION-SPECIFIC ANTIGEN-INDUCED BY AN AVIAN-SARCOMA VIRUS [J].

BRUGGE, JS ;

ERIKSON, RL .

NATURE, 1977, 269 (5626) :346-348

[34]

Maximizing the Therapeutic Potential of HSP90 Inhibitors [J].

Butler, Lisa M. ;

Ferraldeschi, Roberta ;

Armstrong, Heather K. ;

Centenera, Margaret M. ;

Workman, Paul .

MOLECULAR CANCER RESEARCH, 2015, 13 (11) :1445-1451

[35]

Bistability in the Rac1, PAK, and RhoA Signaling Network Drives Actin Cytoskeleton Dynamics and Cell Motility Switches [J].

Byrne, Kate M. ;

Monsefi, Naser ;

Dawson, John C. ;

Degasperi, Andrea ;

Bukowski-Wills, Jimi-Carlo ;

Volinsky, Natalia ;

Dobrzynski, Maciej ;

Birtwistle, Marc R. ;

Tsyganov, Mikhail A. ;

Kiyatkin, Anatoly ;

Kida, Katarzyna ;

Finch, Andrew J. ;

Carragher, Neil O. ;

Kolch, Walter ;

Nguyen, Lan K. ;

von Kriegsheim, Alex ;

Kholodenko, Boris N. .

CELL SYSTEMS, 2016, 2 (01) :38-48

[36]

Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: Implication in actin-based motility [J].

Carlier, MF ;

Laurent, V ;

Santolini, J ;

Melki, R ;

Didry, D ;

Xia, GX ;

Hong, Y ;

Chua, NH ;

Pantaloni, D .

JOURNAL OF CELL BIOLOGY, 1997, 136 (06) :1307-1322

[37]

A COMMON BICYCLIC PROTEIN-KINASE CASCADE INACTIVATES THE REGULATORY ENZYMES OF FATTY-ACID AND CHOLESTEROL-BIOSYNTHESIS [J].

CARLING, D ;

ZAMMIT, VA ;

HARDIE, DG .

FEBS LETTERS, 1987, 223 (02) :217-222

[38]

CARLSON CA, 1973, J BIOL CHEM, V248, P378

[39]

Identification of cardiac-specific myosin light chain kinase [J].

Chan, Jason Y. ;

Takeda, Morihiko ;

Briggs, Laura E. ;

Graham, Megan L. ;

Lu, Jonathan T. ;

Horikoshi, Nobuo ;

Weinberg, Ellen O. ;

Aoki, Hiroki ;

Sato, Naruki ;

Chien, Kenneth R. ;

Kasahara, Hideko .

CIRCULATION RESEARCH, 2008, 102 (05) :571-580

[40]

PKC-Dependent Phosphorylation of eNOS at T495 Regulates eNOS Coupling and Endothelial Barrier Function in Response to G+ -Toxins [J].

Chen, Feng ;

Kumar, Sanjiv ;

Yu, Yanfang ;

Aggarwal, Saurabh ;

Gross, Christine ;

Wang, Yusi ;

Chakraborty, Trinad ;

Verin, Alexander D. ;

Catravas, John D. ;

Lucas, Rudolf ;

Black, Stephen M. ;

Fulton, David J. R. .

PLOS ONE, 2014, 9 (07)

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