Tumor necrosis factor receptor family members in the immune system

被引：133

作者：

Gravestein, LA ^{[1
]}

Borst, J ^{[1
]}

机构：

[1] Netherlands Canc Inst, Div Cellular Biochem, NL-1066 CX Amsterdam, Netherlands

来源：

SEMINARS IN IMMUNOLOGY | 1998年 / 10卷 / 06期

关键词：

signal transduction; death domain; TRAF; tissue distribution; knock out mice;

D O I：

10.1006/smim.1998.0144

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The tumor nemesis factor (TNF) receptor family contains death receptors, which have a cytoplasmic death domain and can induce apoptosis, as well as receptors with no apparent homology in the cytoplasmic tail. This second group of receptors binds TNF receptor-associated factors (TRAFs), which are implicated in gene regulation and anti-apoptotic signaling. A bewildering variety of TNF receptor family members and their ligands are expressed on cells of the immune system. Based on the pattern of expression of receptors and ligands and based on the phenotype elf available knock out mice, we summarize at which stages in lymphoid development and/or the peripheral immune response the various TNF receptor family members may play a role.

引用

页码：423 / 434

页数：12

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