Field-effect saccharide sensing using AlGaN/GaN heterostructures and boronic acid based chemical receptors

被引:9
作者
Schuller, Tim A. [1 ]
Kuball, Martin [1 ]
Flower, Stephen E. [2 ]
James, Tony D. [2 ]
Fossey, John S. [3 ]
Marcon, Denis [4 ]
Das, Jo [4 ]
Degroot, Stefan [4 ]
Germain, Marianne [4 ]
Sarua, Andrei [1 ]
机构
[1] Univ Bristol, HH Wills Phys Lab, Sch Phys, Bristol BS8 1TL, Avon, England
[2] Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England
[3] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England
[4] IMEC, B-3001 Louvain, Belgium
来源
SENSORS AND ACTUATORS B-CHEMICAL | 2011年 / 160卷 / 01期
基金
英国工程与自然科学研究理事会;
关键词
Biosensors; FET; GaN; Saccharide; Boronic acid; GLUCOSE; SPECTROSCOPY; MONOLAYERS; SENSORS;
D O I
10.1016/j.snb.2011.09.029
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
We demonstrate a novel field-effect saccharide sensor device using an AlGaN/GaN heterostructure functionalized with a chemical receptor, featuring a thiol group, alkane chain linker and a simple boronic acid. Fabricated devices were demonstrated to electronically detect buffered saccharide solutions (fructose, galactose and glucose) of varying concentrations. These results provide proof-of-concept for the development AlGaN/GaN-based sensor devices incorporating boronic acid receptor chemistry. (C) 2011 Elsevier B.V. All rights reserved.
引用
收藏
页码:1078 / 1081
页数:4
相关论文
共 23 条
[1]   Catalytic activity of enzymes immobilized on AlGaN/GaN solution gate field-effect transistors [J].
Baur, B. ;
Howgate, J. ;
von Ribbeck, H. -G. ;
Gawlina, Y. ;
Bandalo, V. ;
Steinhoff, G. ;
Stutzmann, M. ;
Eickhoff, M. .
APPLIED PHYSICS LETTERS, 2006, 89 (18)
[2]  
Bettelheim F., 2009, INTRO ORGANIC BIOCH
[3]   Detection of chloride ions using an integrated Ag/AgCl electrode with AlGaN/GaN high electron mobility transistors [J].
Hung, S. C. ;
Wang, Y. L. ;
Hicks, B. ;
Pearton, S. J. ;
Dennis, D. M. ;
Ren, F. ;
Johnson, J. W. ;
Rajagopal, P. ;
Roberts, J. C. ;
Piner, E. L. ;
Linthicum, K. J. ;
Chi, G. C. .
APPLIED PHYSICS LETTERS, 2008, 92 (19)
[4]   High resolution x-ray photoelectron spectroscopy measurements of octadecanethiol self-assembled monolayers on Au(111) [J].
Ishida, T ;
Hara, M ;
Kojima, I ;
Tsuneda, S ;
Nishida, N ;
Sasabe, H ;
Knoll, W .
LANGMUIR, 1998, 14 (08) :2092-2096
[5]  
James T.D. P., 2006, BORONIC ACIDS SACCHA
[6]  
James TD, 2002, TOP CURR CHEM, V218, P159
[7]  
James TD, 2005, BORONIC ACIDS: PREPARATION AND APPLICATIONS IN ORGANIC SYNTHESIS AND MEDICINE, P441, DOI 10.1002/3527606548.ch12
[8]   Electrical detection of biomaterials using AlGaN/GaN high electron mobility transistors [J].
Kang, B. S. ;
Wang, H. T. ;
Ren, F. ;
Pearton, S. J. .
JOURNAL OF APPLIED PHYSICS, 2008, 104 (03)
[9]   Glucose Oxidase-graphene-chitosan modified electrode for direct electrochemistry and glucose sensing [J].
Kang, Xinhuang ;
Wang, Jun ;
Wu, Hong ;
Aksay, Ilhan A. ;
Liu, Jun ;
Lin, Yuehe .
BIOSENSORS & BIOELECTRONICS, 2009, 25 (04) :901-905
[10]   Photochemical functionalization of gallium nitride thin films with molecular and biomolecular layers [J].
Kim, Heesuk ;
Colavita, Paula E. ;
Metz, Kevin M. ;
Nichols, Beth M. ;
Sun, Bin ;
Uhlrich, John ;
Wang, Xiaoyu ;
Kuech, Thomas F. ;
Hamers, Robert J. .
LANGMUIR, 2006, 22 (19) :8121-8126